Results 51 to 60 of about 35,088 (292)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Algorithm curation and the emergence of filter bubbles

, 2022
Social networks and news outlets entrust content curation to specialised algorithms from the broad family of recommender systems. Companies attempt to increase engagement by connecting users with ideas they are more likely to agree with. Eli Pariser, the author of the term filter bubble, suggested that it might come as a price of narrowing users ...
Fuckner, Marcio, Bašić, Suzana, Wiggers, Pascal   +2 more
openaire   +3 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Reframing the filter bubble through diverse scale effects in online music consumption

Scientific Reports
The impact of platforms’ algorithmic curation devices on users’ consumption diversity has long since been the subject of debate in popular culture and academia alike.
Dougal Shakespeare, Victor Chareyron, Camille Roth   +2 more
doaj   +1 more source

Montage, Memories, Machine

Media Theory
This paper explores the entanglement of human perception and machine operations in contemporary photographic culture, using montage as a conceptual resource to interrogate our understanding of photography in the context of computational vision and ...
Jasmin Pfefferkorn
doaj   +1 more source

Mitigating Gender Bias in Machine Learning Data Sets

, 2020
Artificial Intelligence has the capacity to amplify and perpetuate societal biases and presents profound ethical implications for society. Gender bias has been identified in the context of employment advertising and recruitment tools, due to their ...
A Caliskan, CR Caldas-Coulthard, E Shor, GM Vefali, H Motschenbacher, K Frith, M Pearce, N Garg, P Ingham, R Sigley, S Leavy, S Mills, S Mollin, S Romaine, W Martyna   +14 more
core   +1 more source

Data fluidity in DARIAH -- pushing the agenda forward [PDF]

, 2016
This paper provides both an update concerning the setting up of the European DARIAH infrastructure and a series of strong action lines related to the development of a data centred strategy for the humanities in the coming years.
Baillot, Anne, Mertens, Mike, Romary, Laurent   +2 more
core   +6 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Algorithmic Empowerment and Its Impact on Circular Economy Participation: An Empirical Study Based on Human–Machine Collaborative Decision-Making Mechanisms

Journal of Theoretical and Applied Electronic Commerce Research
At the intersection of the circular economy and artificial intelligence (AI), high-value secondhand trading faces a “triple decision dilemma” of cognitive overload, trust risk, and emotional attachment. To address the limits of traditional human-centered
Xingjun Ru, Le Liu, Min Chen
doaj   +1 more source

Collaboratively Patching Linked Data [PDF]

, 2012
Today's Web of Data is noisy. Linked Data often needs extensive preprocessing to enable efficient use of heterogeneous resources. While consistent and valid data provides the key to efficient data processing and aggregation we are facing two main ...
Hercher, Johannes, Knuth, Magnus, Sack, Harald   +2 more
core