Results 21 to 30 of about 30,818 (266)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
DIDADTIC TOOLS FOR THE STUDENTS’ ALGORITHMIC THINKING DEVELOPMENT
Образование и наука, 2017 Introduction. Modern engineers must possess high potential of cognitive abilities, in particular, the algorithmic thinking (AT). In this regard, the training of future experts (university graduates) of technical specialities has to provide the knowledge ...
T. P. Pushkaryeva +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
How Algorithmic Management Influences Gig Workers’ Job Crafting
Behavioral SciencesAlgorithmic management, as a digital management tool in the gig economy, has become a hotspot of concern at the intersection of theory and practice. However, there is a lack of research on the mechanisms and boundary conditions through which algorithmic ...
Rong Liu, Haorong Yin
doaj +1 more source
The Use of Algorithmic Skeletons to Design Actor-Based Parallel Algorithms
Современные информационные технологии и IT-образование, 2020 The paper proposes a method for writing parallel algorithms. Our goal was to make a detailed description of concurrency while carrying no dependencies in programming language or underlying parallel architecture.
Sergey Vostokin, Irina Bobyleva
doaj +1 more source
Greedy Algorithms Make Efficient Mechanisms [PDF]
Proceedings of the Sixteenth ACM Conference on Economics and Computation, 2015 We study mechanisms that use greedy allocation rules and pay-your-bid pricing to allocate resources subject to a matroid constraint. We show that all such mechanisms obtain a constant fraction of the optimal welfare at any equilibrium of bidder behavior, via a smoothness argument.
Lucier, Brendan, Syrgkanis, Vasilis
openaire +2 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
RUDN Journal of Public AdministrationGovernments worldwide are increasingly turning to artificial intelligence (AI) and algorithmic systems to improve service delivery, manage resources, and respond to citizens’ needs. These tools promise efficiency, precision, and cost savings, making them
Bhargav R. Moundekar, Gauri S. Sharma
doaj +1 more source
Energy-efficient algorithms [PDF]
Communications of the ACM, 2010 Algorithmic solutions can help reduce energy consumption in computing environs.
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source