Results 31 to 40 of about 290 (247)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Theories and Dimensions of Algorithmic Power, between Agency and Domination

Scienza & Politica
This article reviews the critical and sociological literature on algorithms and AI in light of anthropocentric social theories of power and its dimensions.
Massimo Airoldi
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mind Snatchers of the Anthropocene. Can Aspects Dawn within the Gulag Architectonic? [PDF]

The Polish Journal of Aesthetics, 2019
It could be said that the real challenge of the Anthropocene is to confront the question of a converted gaze, in a way that requires and exceeds Kant’s notion of an extraterrestrial standpoint of standpoints.
Daniel Ross
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Il regime di verità digitale. Dalla governamentalità algoritmica a un nuovo Stato di diritto [PDF]

La Deleuziana, 2016
This text is a transcription of Rouvroy’s presentation on 7th October 2014 at the “Digital Studies” seminar series at the Centre Georges Pompidou. This seminar series, organised by the French philosopher Bernard Stiegler, question the influence of ...
Antoinette Rouvroy, Bernard Stiegler
doaj  

Prevalence of Systemic Lupus Erythematosus in Australia, 2010–2022: A Population‐Based Study Using Linked National Administrative Health Data

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a heterogenous inflammatory condition with widely varying global prevalence estimates. The frequency of SLE in the general population of Australia has been reported to be notably lower than contemporary estimates in countries such as the United States or United Kingdom, at 19 to 39 per 100,000 as opposed ...
Lucinda Roper, Rachel Black, Joanna Tieu, Winnie Chen, Matthew Parker, Catherine Hill, Natasha Nassar, Mandana Nikpour   +7 more
wiley   +1 more source

The arrival of AI to the cities: platform urbanism and new regimes of governmentality

Revista CIDOB d'Afers Internacionals
This paper analyses “platform urbanism” as a post-biopolitical dispositive of domination and subjectivation characteristic of the “performance societies” of the 21st century.
José Luis Blasco Ejarque, Francisco Javier Tirado   +1 more
doaj   +1 more source

Pensare l'impersonale tra vitalismo e macchinismo. Come resistere alla governamentalità algoritmica? [PDF]

La Deleuziana, 2016
Deleuze has left to with two texts, ‘Post-scriptum sur les sociétés de contrôle’ and L’immanence: une vie.., which constitute his heritage. These two essays seem to stand far apart from each other, because while the first talks about the risk that ...
Natascia Tosel
doaj