Results 51 to 60 of about 188,895 (269)
Algorithmic Support for Railway Disruption Management [PDF]
, 2009 Disruptions of a railway system are responsible for longer travel times and much discomfort for the passengers. Since disruptions are inevitable, the railway system should be prepared to deal with them effectively.
Huisman, D. (Dennis), Kroon, L.G. (Leo)
core
Critical mutation rate has an exponential dependence on population size in haploid and diploid populations [PDF]
, 2013 Understanding the effect of population size on the key parameters of evolution is particularly important for populations nearing extinction. There are evolutionary pressures to evolve sequences that are both fit and robust.
Aston, E, Channon, A, Day, C, Knight, CG
core +5 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Algorithmic management in the focus of sociology of technology
RUDN journal of SociologyThis article considers the managerial aspect of digital transformation - various programs and infrastructure that have recently received the general name “algorithmic management”. The boom in the use of such tools occurred during the covid-19 pandemic as
M. A. Yudina
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Self-tracking modes: reflexive self-monitoring and data practices [PDF]
, 2014 The concept of ‘self-tracking’ (also referred to as life-logging, the quantified self, personal analytics and personal informatics) has recently begun to emerge in discussions of ways in which people can voluntarily monitor and record specific features ...
Deborah Lupton
core +2 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Navigating the maze: the effects of algorithmic management on employee performance
Humanities & Social Sciences CommunicationsRecent computer science advancements are now integrated into the workplace, where management increasingly uses algorithm systems. However, despite numerous studies focusing on the impact of algorithms on employees, research on employee creative and ...
Mengzhe Liu +4 more
doaj +1 more source
Вестник Пермского университета: Серия Экономика, 2023 Introduction. These days, extra institutional restrictions call for new methods of managing the costs for importing equipment at the national enterprises. Purpose.
Elena Valer’evna Bazueva +2 more
doaj +1 more source