Results 51 to 60 of about 281,740 (353)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Lattice gradient flows (de-)stabilizing topological sectors

Journal of High Energy Physics
We investigate the stability of topological charge under gradient flow taking the admissibility condition into account. For the SU(2) Wilson gauge theory with β = 2.45 and L 4 = 124, we numerically show that the gradient flows with the Iwasaki and DBW2 ...
Yuya Tanizaki, Akio Tomiya, Hiromasa Watanabe   +2 more
doaj   +1 more source

Selected Items in Jet Algorithms

, 2008
I provide a very brief overview of recent developments in jet algorithms, mostly focusing on the issue of infrared-safety.Comment: 3 pages.
Bozzi, Giuseppe
core   +1 more source

Animating the development of Social Networks over time using a dynamic extension of multidimensional scaling [PDF]

, 2008
The animation of network visualizations poses technical and theoretical challenges. Rather stable patterns are required before the mental map enables a user to make inferences over time.
De Nooy, Wouter, Leydesdorff, Loet, Schank, Thomas, Scharnhorst, Andrea   +3 more
core   +6 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Exploiting stochastic locality in lattice QCD: hadronic observables and their uncertainties

Journal of High Energy Physics, 2023
Because of the mass gap, lattice QCD simulations exhibit stochastic locality: distant regions of the lattice fluctuate independently. There is a long history of exploiting this to increase statistics by obtaining multiple spatially-separated samples from
Mattia Bruno, Marco Cè, Anthony Francis, Patrick Fritzsch, Jeremy R. Green, Maxwell T. Hansen, Antonio Rago   +6 more
doaj   +1 more source

Statistical and Computational Tradeoff in Genetic Algorithm-Based Estimation

, 2017
When a Genetic Algorithm (GA), or a stochastic algorithm in general, is employed in a statistical problem, the obtained result is affected by both variability due to sampling, that refers to the fact that only a sample is observed, and variability due to
Battaglia, Francesco, Rizzo, Manuel
core   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Numerical determination of the width and shape of the effective string using Stochastic Normalizing Flows

Journal of High Energy Physics
Flow-based architectures have recently proved to be an efficient tool for numerical simulations of Effective String Theories regularized on the lattice that otherwise cannot be efficiently sampled by standard Monte Carlo methods.
Michele Caselle, Elia Cellini, Alessandro Nada   +2 more
doaj   +1 more source

Entanglement entropy from non-equilibrium Monte Carlo simulations

Journal of High Energy Physics, 2023
We study the entanglement entropy in lattice field theory using a simulation algorithm based on Jarzynski’s theorem. We focus on the entropic c-function for the Ising model in two and in three dimensions: after validating our algorithm against known ...
Andrea Bulgarelli, Marco Panero
doaj   +1 more source