Results 161 to 170 of about 132,096,113 (307)

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Fabio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

The polymorphic gateway between structure and algorithms: Beyond CSPs

, 2018
Presented on December 3, 2018 at 11:00 a.m. in the Klaus Advanced Computing Building, Room 1116E.Venkatesan Guruswami is a Professor in the School of Computer Science at Carnegie Mellon University.
Guruswami, Venkat
core  

Machine learning-based prediction and quality control of meat and meat products: applications for intelligent quality management in the meat industry. [PDF]

Food Sci Anim Resour
Kim YJ, Kwon HC, Cha JY, Lee S, Kim TK, Kang MC, Park MK, Choi YS.   +7 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Machine Learning Optimization Algorithms for Clustering Regions and Emergency Management: A Review

Journal of Multidisciplinary Healthcare
Sampson Akwafuo,1 Prachi Fnu,2 Daniel Quezada1 1Department of Computer Science, California State University, Fullerton, CA, USA; 2Department of Computer Engineering, California State University, Fullerton, CA, USACorrespondence: Sampson Akwafuo ...
Akwafuo S, Fnu P, Quezada D
doaj  

The Digital Transformation of Rehabilitation Medicine: A Narrative Review of Artificial Intelligence Innovations, Clinical Integration, and Future Paradigms. [PDF]

J Eval Clin Pract
Wu H, Yang Y, Wang L, Su H, Li X.
europepmc   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Applying Visualization for Teaching Scheduling Algorithms in Computer Science

, 2017
Using animation in teaching has become more popular in the twenty-first century in universities and education organizations. It makes understanding the challenging concepts much easier than using the traditional methods to explain them.
Alkhazl, Fatimah
core  

RLBWT-based LCP computation in compressed space for terabase-scale pangenome analysis. [PDF]

Bioinformatics
Sanaullah A, Brown NK, Shakya P, Deegutla A, Naseri A, Langmead B, Zhi D, Zhang S.   +7 more
europepmc   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source