Results 171 to 180 of about 297,416 (350)
Calmodulin assists during co‐translational folding of the KV7.2 channel calcium responsive domain
Protein Science, Volume 35, Issue 5, May 2026.Abstract
In vivo, the majority of nascent protein chains begin folding during translation in order to reach their native structure. While the importance of co‐translational folding has become increasingly clear, the specific mechanisms underlying the coordination between the ribosome, the nascent chain and interacting partners are still uncertain. Here,Arantza Muguruza‐Montero, Jack R. Tait, Sara M‐Alicante, Ane Metola, Eider Nuñez, Janire Urrutia, Vanda Sunderlíková, Alexandros Katranidis, Gunnar von Heijne, Sander J. Tans, Alvaro Villarroel +10 morewiley +1 more sourceReal‐World Effectiveness and Safety of Upadacitinib in Crohn's Disease: Insights From the Eneida Registry
United European Gastroenterology Journal, Volume 14, Issue 4, May 2026.ABSTRACT Background
Upadacitinib (UPA) is the first oral Janus kinase (JAK) inhibitor approved for the treatment of Crohn's disease (CD). Real‐world data, particularly from large nationwide cohorts, remain limited. This study aimed to evaluate the real‐world effectiveness, safety, and treatment persistence of UPA in patients with CD.M. Iborra, B. Botella, M. D. Martín‐Arranz, D. Ceballos, C. Martínez‐Pascual, A. Garrido, P. Varela, M. Moreta, E. Brunet‐Mas, Y. González‐Lama, E. Rodríguez‐González, M. Vicuña, J. P. Gisbert, I. Ordás, F. Argüelles‐Arias, J. Tosca‐Cuquerella, R. Vicente‐Lidón, M. Sierra‐Ausín, I. Rodríguez‐Lago, D. Martín‐Rodríguez, J. M. Paredes, B. Sicilia, I. García de la Filia, N. Jiménez, M. Barreiro‐de Acosta, E. Betoré, I. Ferrer‐Bradley, L. García‐Alles, J. M. Huguet, S. Castellet‐Farrús, M. J. García, A. Gutiérrez‐Casbas, Á. Ponferrada‐Díaz, L. Ramos, M. Calafat, I. Vera, C. Suárez‐Ferrer, E. Fernández‐Velado, S. Rodríguez‐Sánchez, A. Mínguez, A. Mancebo, J. Barrio, S. Lario, D. R. de La Cruz, Alejandro Hernández‐Camba, C. Rodríguez‐Gutiérrez, M. Chaparro, E. Ricart, L. Almenara‐Michelena, A. Balaguer, E. Domènech, P. Nos +51 morewiley +1 more sourceEndocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study
Addiction, Volume 121, Issue 5, Page 1179-1189, May 2026.Abstract Aims
To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.María Salud García‐Gutiérrez, Abraham Bailén Torregrosa, Francisco Navarrete, Auxiliadora Aracil‐Fernández, Gabriel Rubio, Jorge Manzanares +5 morewiley +1 more sourceNationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain‐DDR Study
Alimentary Pharmacology &Therapeutics, Volume 63, Issue 10, Page 1390-1397, May 2026.Nationwide implementation of double reflex testing for hepatitis delta in Spain markedly increased anti‐HDV and HDV viral load testing between 2022 and 2024, enabling national seroprevalence estimates. Despite this progress, substantial regional heterogeneity persists, highlighting the need for standardised reflex diagnostic protocols.Ana Alberola, Adolfo de Salazar, Ana Fuentes, Raquel Carracedo, Marta Illescas‐López, María del Carmen Rodríguez Baños, Carolina Freyre, Berta Becerril, Isabel Viciana, Inmaculada López‐Rodríguez, Natalia Montiel, Ana María Domínguez Castaño, María Pilar Luzón‐García, Encarnación Ramírez Arellano, Carmen Liébana‐Martos, Francisco Franco Álvarez de Luna, María del Carmen Lozano, Begoña Palop, Antonio Sampedro, Ana Belén Pérez, Sonia Algarate, Susana Rojo Alba, Pablo Fraile, Dolores Ocete, María Jesús Alcaraz, Juan Carlos Rodríguez, Francisco Javier Hernández‐Felices, Olalla Martínez, Victoria Domínguez, Nieves Orta, Dolores Gómez, Carmen Cortell, Jorge Camacho, Susana Sabater, Luis Ángel Iglesias Sánchez, Yasmina Martín, Aldara Vallejo, Lourdes Molina, María Aroca, Beatriz Castro, Magdalena Lara, María José Pena, Ana Rodríguez‐Fernández, Alejandro González Praetorius, José Joaquín Blas, Alicia Beteta, César Gómez, María José Rodríguez, Soledad Illescas, Melanie Abreu, Julio García Díez, Inocencio Beltrán, Marta Sandoval Torrientes, Ruth Sáez, Teresa Martín, Pilar Tajada Alegre, Belén Lorenzo, María Teresa García Valero, Isabel Jiménez Sansegundo, Susana García‐de Cruz, Sonsoles Garcinuño, Miguel Ángel Sáiz, Santiago Muñoz, Isabel Fernández, Helena Miriam Lorenzo Juanes, María Reyes Vidal‐Acuña, Luz María Moldes, Noelia Calvo, Matilde Trigo, María José Gude, Patricia Ordóñez, Sandra Cortizo, Miriam Blasco, Mayra Sigcha, Iker Falces, Juan Carlos Galán, Ana Arribi, Roberto Alonso, Asunción Iborra, María Jesús del Amor Espín, Eva Cascales, Cayetano Pérez, Pablo Fernández, María Dolores Navarro, María Luz Nuñez, Jorge Galán Ros, Luis Javier Gil‐Gallardo, Ana Miqueleiz, Gabriel Reina, Luis Elorduy, Mikele Macho, Carmen Gómez, Paloma Liendo, Yolanda Salicio, Antonio Aguilera, Federico García +95 morewiley +1 more source