Results 71 to 80 of about 76,179 (307)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

A review of mineral carbonation technologies to sequester CO2 [PDF]

, 2014
Carbon dioxide (CO2) capture and sequestration includes a portfolio of technologies that can potentially sequester billions of tonnes of CO2 per year.
A. Sanna, Andersen, Arickx, Baciocchi, Baciocchi, Baciocchi, Baciocchi, Back, Balaz, Baldyga, Balucan, Becker, Berner, Bobicki, Bodénan, Bonenfant, Bonenfant, Bonfils, Boot-Handford, Boudier, Broecker, Chang, Chang, Chang, Chiang, Cooling, Costa, Daval, Declercq, Dessert, Dilmore, Doucet, Drever, Dri, Dri, Ecke, Eisaman, El-Sheikh, Eloneva, Eloneva, Eloneva, Eloneva, Faatz, Fabian, Fagerlund, Fagerlund, Fagerlund, Falkowski, Favre, Fedoročkova, Fernández Bertos, Fernández Bertos, Flaathen, Folger, G. Caramanna, Gahan, Gerdemann, Gerdemann, Gislason, Gislason, Gislason, Goldberg, Goldberg, Goldberg, Goldberg, Gunning, Gunning, Gunning, Hallenbeck, Haug, Haug, Haug, Highfield, Hitch, Hitch, Holmes, House, House, Huijgen, Huijgen, Huijgen, Huijgen, Huijgen, Huijgen, Huntzinger, Huntzinger, Huntzinger, Hänchen, Hänchen, Iizuka, Johnston, Jones, Jones, Kashef-Haghighi, Katsuyama, Kelem, Kirchofer, Kodama, Kondratenko, Krevor, Krevor, Kuusik, Kwak, Kwak, Kwon, Lackner, Larachi, Lee, Lekakh, Levenspiel, Li, Li, Lin, Lindeboom, M. M. Maroto-Valer, M. Uibu, Maguire, Maroto-Valer, Matter, Matter, Matter, Mayoral, McGrail, Meima, Metz, Monkman, Montes-Hernandez, Montes-Hernandez, Munz, Muriithi, Nduagu, Nicholls, Nyambura, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, Olajire, Olajire, Olsen, Olsen, Olsen, Oskierski, Pacala, Pachauri, Pan, Park, Park, Park, Paukert, Perez-Lopez, Pokrovsky, Polettini, Praetorius, Qiao, R. Kuusik, Raschman, Rau, Reddy, Reddy, Reinhardt, Rendek, Renforth, Rosenthal, Sahoo, Sahu, Said, Salek, Sanna, Sanna, Sanna, Sanna, Santos, Santos, Santos, Santos, Seifritz, Shih, Si, Sigfusson, Sipilä, Soong, Stockmann, Stolaroff, Stolaroff, Sun, Tai, Teir, Teir, Teir, Teir, Teir, Teir, Teramura, Uibu, Uibu, Uibu, Uibu, Van Gerven, Velts, Verduyn, Verduyn, Wang, Wang, Wang, Wang, Wang, Wanjari, Wee, Wilson, Yadav, Yan, Zakharova, Zevenhoven   +214 more
core   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

Advanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen, Wenliang Zhou, Lan Qiu, Han Lai, Mingpan Huang, Qian Li, Wen Yu, Pei‐Yuan Qian, Fuwen Wei   +8 more
wiley   +1 more source

Dynamic Etching‐Induced Cl‐Terminated Ti3C2Clx/Ti3ZnC2 Heterostructure for Ammonia Electrosynthesis and Zinc‐Nitrogen Batteries

Advanced Science, EarlyView.
A stable Ti3C2Clx/Ti3ZnC2 heterostructure, fabricated by dynamic etching, exhibits outstanding electrocatalytic NRR activity (NH3 yield: 20.1 µg h−1 mg−1, FE: 38.1%) in alkaline media. The corresponding Zn‐N2 battery achieves a peak power density of 36.5 µW cm−2 and an NH3 yield of 13.1 µg h−1 mg−1, providing an advanced strategy for NH3 and ...
Yu Wang, Ying Sun, Liqun Ye, Jichi Liu, Hui Li, Yang Fu, Fengzhan Sun, Jieshan Qiu, Chang Yu, Tianyi Ma   +9 more
wiley   +1 more source

Negative activation volume for dielectric relaxation in hydrated rocks

, 2010
Negative defect activation volumes are extremely rare in solids. Here, we report for the first time that this holds in a couple of hydrated rocks for dielectric relaxation by exploring the complex impedance spectra at various pressures and temperatures ...
A.N. Papathanassiou, Endres, Fontanella, Fontanella, I. Sakellis, J. Grammatikakis, Morgan, Morgan, Nettelblad, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Surkov, Uyeda, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Wang   +42 more
core   +1 more source

Engineering an Optogenetic pH‐Modulator in Bacteria

Advanced Science, EarlyView.
ABSTRACT Cells in many naturally occurring organisms routinely cooperate to control their extracellular pH in a dynamic and reversible manner, but this capability has been underexplored in synthetic biology. Here, we sought to engineer a microbial system that switches between two states —high and low extracellular pH— with minimal human intervention ...
Jenevieve Kuang, Olivia J. Armendarez, Wei‐Ting Chang, Matthew M. Hausladen, Shanna Bonanno, Daniel J. Wilson, Neel S. Joshi, Leila F. Deravi   +7 more
wiley   +1 more source

Petrology and Geochemistry of Intrusive Rocks in the Tanjung Area, South Sulawesi, Indonesia: Implications for Magma Origin, Source Materials, and Geodynamic Setting

Iraqi Geological Journal
The origin of magma, source materials, and geodynamic setting of plutonic and volcanic rocks was elucidated by studying the characteristics of the rocks in the Tanjung area, South Sulawesi, Indonesia.
Hasbi Bakri, Imran Imran, Ulva Irvan, Adi Maulana   +3 more
doaj   +1 more source

Release of potassium from rock powder by the yeast Torulaspora globosa

Brazilian Archives of Biology and Technology, 2012
The alteration of minerals in rocks and the availability of elements for plant nutrition require long periods of time, and microorganisms are thought to induce the release of potassium and phosphate from rocks.
Márcia Maria Rosa-Magri, Simoni Helena Avansini, Maria Leonor Lopes-Assad, Sâmia Maria Tauk-Tornisielo, Sandra Regina Ceccato-Antonini   +4 more
doaj   +1 more source

Scalable, Low‐Cost, Freeze‐Resistant Hydrogels by Alkali‐Polyphenol‐Triggered Polymerization for Low‐Temperature Self‐Powered Triboelectric Sensor

Advanced Science, EarlyView.
Leveraging the multidimensional self‐catalytic merits of the alkali‐polyphenol synergistic self‐catalytic platform, this work delineates the intrinsic mechanism governing the regulation of hydrogel properties and puts forward an innovative design paradigm for frost‐tolerant electrode materials, providing critical scientific insights and technical ...
Mengting Zhou, Yaru Bao, Chunpeng Li, Caicai Li, Gaobo Lou, Shaochao Sun, Zhezhe Zhou, Gaojie Jiao, Xiaochun Zhang, Pingan Song, Dan Sun   +10 more
wiley   +1 more source