Results 221 to 230 of about 232,220 (312)

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Safety of 12‐Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

Antibacterial, antibiofilm, and metabolomic profiling of the novel freshwater fungi Longipedicellata megafusiformis and Wicklowia fusiformispora. [PDF]

Sci Rep
Khruengsai S, Sripahco T, Kittakoop P, Pripdeevech P.   +3 more
europepmc   +1 more source

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

Indirect identification of 4,21-dehydrocorynenantheinaldehyde as an intermediate in the biosynthesis of ajmalicine and related alkaloids [PDF]

, 1978
Hoyer, G. A., Rüffer, Martina, Stöckigt, Joachim, Zenk, Meinhart H.   +3 more
core  

Influence of Plant Age and Endophyte Status on the Nematotoxicity of <i>Festulolium loliaceum</i> to <i>Trichodorus primitivus</i> and Quantification of Active Phytochemicals. [PDF]

Toxins (Basel)
Mwangi NG, Gillanders TJ, Stevens M, Wright AJD, Edwards SG, Hare MC, Back MA.   +6 more
europepmc   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Elevated quinolizidine alkaloid content in grains of sweet narrow-leaved lupins when intercropped with oats. [PDF]

J Sci Food Agric
Schlup Y, Mulder PP, Kalli S, de Nijs M, Six J, Vogelgsang S.   +5 more
europepmc   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Comparison of metabolite differences and pharmacologically active constituents between <i>Piper longum</i> and <i>Piper sarmentosum</i> based on non-targeted metabolomics. [PDF]

PeerJ
Liu L, Li Q, Alami M, Shen R, Zhu J, Zhang Q, Liu Y, Mei Z.   +7 more
europepmc   +1 more source