Results 81 to 90 of about 232,220 (312)

Predictive analytical workflow for rapid structure elucidation and in silico toxicological qualification of an unidentified impurity in cefixime granules for oral suspension

Acta Pharmaceutica
During in-use stability testing of cefixime granules for oral suspension, an impurity with a relative retention time of 0.19 was consistently detected and increased during storage.
Mitrevska Ivana, Chachorovska Marina, Petrushevski Gjorgji   +2 more
doaj   +1 more source

Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid [PDF]

, 2013
Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were ...
Ali, Saqib, Almazeb, Muhammad, Clements, Carol, Ferro, Valerie, Gray, Alexander, Igoli, John, Khan, M Rafiullah, Rashid, Mamoon-Ur, Semaan, Dima, Shah, Syed Qaisar   +9 more
core   +1 more source

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Мultivariate analysis for rapid screening and prediction of solid-state compatibility in pharmaceutical preformulation studies-paving the road for machine learning

Macedonian Journal of Chemistry and Chemical Engineering
Multivariate analysis models were developed to evaluate the results obtained from a compatibility study designed for ibuprofen with a large group of different types of excipients, as a possible approach for rapid screening of the incompatibility between
Elena Cvetkovska Bogatinovska, Nikola Geškovski, Gjorgji Petrushevski, Viktor Stefov   +3 more
doaj   +1 more source

A Complex Stereochemical Relay Approach To The Antimalarial Alkaloid Ocimicide A1. Evidence For A Structural Revision [PDF]

, 2017
Ocimicide A1 (1) and the semisynthetic derivative ocimicide A2 (2) are highly potent antimalarial agents efficacious against chloroquine-sensitive and -resistant Plasmodium falciparum strains with IC50 values in the nanomolar and picomolar range ...
Herzon, S. B., Mamoun, C. B., Nikolayevskiy, H., Rablen, Paul R., Tun, M. K. M.   +4 more
core   +2 more sources

Protective Effects of Alkaloid Compounds from Nelumbinis Plumula on tert-Butyl Hydroperoxide-Induced Oxidative Stress

Molecules, 2013
This study was conducted to investigate the effect of Nelumbinis Plumula total alkaloid (NPA) and its main alkaloid components on oxidative stress induced by tert-butyl hydroperoxide (t-BHP) in the human hepatocellular HepG2 cell line.
Ze-Bin Guo, Bao-Dong Zheng, Shao-Xiao Zeng, Long-Tao Zhang, Yi Zhang, Yong Xie   +5 more
doaj   +1 more source

Comparative study of the vibrational optical activity techniques in structure elucidation : the case of galantamine [PDF]

, 2019
The absolute configuration of the alkaloid galantamine was studied using a range of solution-state techniques; nuclear magnetic resonance (NMR), vibrational circular dichroism (VCD), and Raman optical activity (ROA). While the combined use of NMR and VCD
Bultinck, Patrick, De Gussem, Ewoud, Herrebout, Wouter A., Johannessen, Christian, Tehrani, Kourosch Abbaspour   +4 more
core   +2 more sources

Real‐time monitoring of root dielectric properties for assessing crop plant damage caused by foliar application of glyphosate

Applications in Plant Sciences, EarlyView.
Abstract Premise There is a knowledge gap regarding how foliar injury and restricted water uptake can be detected by measuring root dielectric response. This pot study nondestructively evaluated the efficiency of real‐time dielectric measurement to monitor the effects of glyphosate spraying.
Imre Cseresnyés, Anna Füzy, Tünde Takács   +2 more
wiley   +1 more source

Study of Antibacterial and Antifungal Efficacy of Alkaloid Isolated from Nutmeg (Myristica fragrans)

Journal of Pure and Applied Microbiology, 2019
The present study included the isolation of alkaloids from the nutmeg fruit (Myristica fragrans) where one of the alkaloid compounds in the nutmeg fruit was found, which is the existence of the aromatic and has carbonyl and phenol groups in addition to ...
Bushra A.M Abdul Azeez, Fatima S. Sebah, Inaam M.N. Alrubayae   +2 more
doaj   +1 more source

Indole diterpenoid natural products as the inspiration for new synthetic methods and strategies. [PDF]

, 2017
Indole terpenoids comprise a large class of natural products with diverse structural topologies and a broad range of biological activities. Accordingly, indole terpenoids have and continue to serve as attractive targets for chemical synthesis.
Corsello, Michael A, Garg, Neil K, Kim, Junyong   +2 more
core   +1 more source