Results 151 to 160 of about 1,498 (184)

Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells

Cell and Tissue Research, 2021
RNA N6-methyladenosine (m6A) is essential for many bioprocesses in many species, but its role in goat testis development remains elusive, especially alkB homolog 5 (ALKBH5), one of the m6A demethylases. To this end, nine healthy Haimen goats of different ages were chosen randomly to provide testes. The results showed that the expression level of ALKBH5
Zifei Liu, Yu Cai, Mingtian Deng, Dongxu Li, Qingqing Leng, Liangyue Shi, Yutong Tang, Feng Wang, Yongjie Wan   +8 more
openaire   +2 more sources

ALKB homolog 5 (ALKBH5)-induced circPUM1 upregulation facilitated the progression of neuroblastoma via miR-423–5p/PA2G4 axis

Pathology - Research and Practice, 2023
The oncogenic role of circPUM1 has been revealed in multiple cancers. Nevertheless, the specific role and molecular mechanism of circPUM1 in neuroblastoma (NB) have never been reported.The expression of genes was detected using RT-qPCR and Western Blot assay.
Lin, Liu, He, Zhao, Jing, Li, Jie, Huang, Yunyun, Xu, Xiaolu, Li, Yi, Wu, Ping, Li, Xinxian, Guan, Ruze, Tang   +9 more
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alkB homologs in thermophilic bacteria of the genus Geobacillus

Molecular Biology, 2008
Screening of alkane hydroxylase genes (alkB) was performed in the thermophilic aerobic bacteria of the genus Geobacillus. Total DNA was extracted from the biomass of 11 strains grown on the mixture of saturated C10-C20 hydrocarbons, PCR amplification of fragments of alkB genes was performed with degenerate oligonucleotide primers, PCR products were ...
T P, Turova, T N, Nazina, E M, Mikhaĭlova, T A, Rodionova, A N, Ekimov, A V, Mashukova, A B, Poltaraus   +6 more
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Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells

Current Cancer Drug Targets, 2012
Castrate resistant prostate cancer (CRPC) is a disease that is resistant to both hormone therapy and chemotherapy. At present, no curative therapy for CRPC has been established. Therefore, it is necessary to determine a novel molecular target for the development of therapeutic agents.
K, Koike, Y, Ueda, H, Hase, K, Kitae, Y, Fusamae, S, Masai, T, Inagaki, Y, Saigo, S, Hirasawa, K, Nakajima, I, Ohshio, Y, Makino, N, Konishi, H, Yamamoto, K, Tsujikawa   +14 more
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Association of AlkB homolog 3 expression with tumor recurrence and unfavorable prognosis in hepatocellular carcinoma

Journal of Gastroenterology and Hepatology, 2018
AbstractBackground and AimThe mammalian AlkB homolog protein family has been reported to promote tumor cell invasion and metastasis of human cancer. However, the expression status and clinical significance of AlkB homolog 3 (ALKBH3) in hepatocellular carcinoma (HCC) have not been reported yet.MethodsIn the present study, we investigated the protein ...
Qian Wang, Gang Wang, Yi Wang, Chaoxu Liu, Xianli He   +4 more
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Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a poor prognosis. As a tumor inhibitor, the specific tumor suppressor mechanism of Sirtuin4(SIRT4) in PDAC remains elusive. In this study, SIRT4 was found to inhibit PDAC by impacting mitochondrial homeostasis. SIRT4 deacetylated lysine 547 of SEL1L and increased the protein level
Dongnan, Ping, Xiaofan, Pu, Guoping, Ding, Chaolei, Zhang, Junbin, Jin, Chengjie, Xu, Jiazheng, Liu, Shengnan, Jia, Liping, Cao   +8 more
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A new method for the detection of alkane-monooxygenase homologous genes (alkB) in soils based on PCR-hybridization

Journal of Microbiological Methods, 2006
An improved method was developed that allowed the specific detection of the gene alkB (coding for the rubredoxin dependent alkane monooxygenase) from bacteria without any obvious strain specific discrimination using a combination of PCR and hybridization.
Karin, Kloos, Jean Charles, Munch, Michael, Schloter   +2 more
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A positive feedback loop between AlkB homolog 5 and miR-193a-3p promotes growth and metastasis in esophageal squamous cell carcinoma

Human Cell, 2020
Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies worldwide. miR-193a-3p acts as an oncogene or tumor suppressor in different cancers. However, the functional role and regulatory mechanism of miR-193a-3p in ESCC remain to be elucidated.
Jinliang Xue, Peng Xiao, Xiangdong Yu, Xiao Zhang   +3 more
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AlkB Homolog 5 Regulates Hexokinase 2‐Mediated Glycolysis and Participates in the Progression of Endometriosis

The FASEB Journal
ABSTRACT Endometriosis is a common gynecological endocrine disease with unclear pathogenesis. Evidence suggests enhanced aerobic glycolysis in ectopic endometrium of endometriosis. The role of N6‐methyladenosine (m6A) modification in female reproductive diseases has been revealed in recent years, and it is involved in the regulation ...
Jun‐Jun Liu, Yu‐Qing Fang, Wen‐Qian Xiong, Heng‐Wei Liu, Jing‐Yi Li, Xiu‐Ping Wang, Hua‐Jing Wang, Ling Zhang, Yi Liu   +8 more
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MPN- and Real-Time-Based PCR Methods for the Quantification of Alkane Monooxygenase Homologous Genes (alkB) in Environmental Samples

2009
Hydrocarbons are major contaminants of soil ecosystems as a result of uncontrolled oil spills and wastes disposal into the environment. Ecological risk assessment and remediation of affected sites is often constrained due to lack of suitable prognostic and diagnostic tools that provide information of abiotic-biotic interactions occurring between ...
Alfredo, Pérez-de-Mora, Stephan, Schulz, Michael, Schloter   +2 more
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