Results 71 to 80 of about 1,498 (184)

The Preclinical Effects and Mechanisms of Biofield Therapy on Pancreatic Cancer Cell Growth and Metastasis

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background The high mortality of pancreatic ductal adenocarcinoma (PDAC) underscores the need for novel treatments. We investigated the potential role of human biofield therapy (BT) in modifying tumorigenic processes in murine and human PDAC cells through a series of in vitro and in vivo studies.
Peiying Yang, Daoyan Wei, Sharmistha Chakraborty, Phuong Nguyen, Andrew Cusimano, Defeng Deng, Shafaqmuhammad Iqbal, Monica Nelson, Meng Cui, Jianliang Dai, Mihai Gagea, Richard Wagner, Yisheng Li, Lorenzo Cohen   +13 more
wiley   +1 more source

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network [PDF]

, 2011
Background Vaccine literature indexing is poorly performed in PubMed due to limited hierarchy of Medical Subject Headings (MeSH) annotation in the vaccine field.
Eva L Feldman, Junguk Hur, Yongqun He, Zuoshuang Xiang   +3 more
core   +3 more sources

Molecular Cloning and Functional Analysis of a Human cDNA Encoding an Escherichia Coli AlkB Homolog, a Protein Involved in DNA Alkylation Damage Repair [PDF]

Nucleic Acids Research, 1996
The Escherichia coli AlkB protein is involved in protecting cells against mutation and cell death induced specifically by SN2-type alkylating agents such as methyl methanesulfonate (MMS). A human cDNA encoding a polypeptide homologous to E.coli AlkB was discovered by searching a database of expressed sequence tags (ESTs) derived from high throughput ...
Y F, Wei, K C, Carter, R P, Wang, B K, Shell   +3 more
openaire   +2 more sources

M6A demethylase ALKBH5 mediated Igfbp4 mRNA m6A modification drives fibroblast activation and pathological upper airway fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
ALKBH5‐mediated m6A modification of Igfbp4 mRNA drives fibroblast activation and pathological collagen deposition in upper airway. Abstract Background Laryngotracheal stenosis (LTS) is a fibroproliferative disease of the upper airway characterised by dysregulated extracellular matrix deposition and fibroblast activation.
Jing Wang, Ziwei Liao, Mengrou Xu, Yangyang Zheng, Bin Hu, Qianhui Xia, Hongming Xu   +6 more
wiley   +1 more source

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1 [PDF]

, 2009
DNA cytosine methylation is crucial for retrotransposon silencing and mammalian development. In a computational search for enzymes that could modify 5-methylcytosine (5mC), we identified TET proteins as mammalian homologs of the trypanosome proteins JBP1
Agarwal, Suneet, Aravind, L, Bandukwala, Hozefa S, Brudno, Yevgeny, Iyer, Lakshminarayan M., Koh, Kian Peng, Liu, David Ruchien, Pastor, William Abraham, Rao, Anjana, Shen, Yinghua, Tahiliani, Mamta V.   +10 more
core   +1 more source

Engineering membrane‐bound alkane monooxygenase from Marinobacter sp. for increased activity in the selective ω‐hydroxylation of linear and branched aliphatic esters

Protein Science, Volume 35, Issue 4, April 2026.
Abstract The regio‐ and stereoselective hydroxylation of unactivated C(sp3)‐H bonds is an important reaction in organic synthesis. While bacterial alkane monooxygenase AlkB catalyzes the terminal hydroxylation of aliphatic esters with excellent regioselectivity, the molecular principles of substrate recognition and selectivity of this integral membrane
Jelena Spasic, Andrea Nigl, Huijin Cheon, Christine L. Kaiserer, Stela Galušić, Elske van der Pol, Lenny Malihan‐Yap, Jin‐Byung Park, Robert Kourist   +8 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Shotgun sequencing of Yersinia enterocolitica strain W22703 (biotype 2, serotype O:9): genomic evidence for oscillation between invertebrates and mammals [PDF]

, 2011
Background Yersinia enterocolitica strains responsible for mild gastroenteritis in humans are very diverse with respect to their metabolic and virulence properties.
Thilo M Fuchs, Katharina Brandt, Mandy Starke, Thomas Rattei   +3 more
core   +1 more source

Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells

Biochemical and Biophysical Research Communications, 2018
Alkbh1 is a mammalian homolog of the Escherichia coli DNA repair enzyme AlkB, an Fe(II) and 2-oxoglutarate dependent dioxygenase that removes alkyl lesions from DNA bases. The human homolog ALKBH1 has been associated with six different enzymatic activities including DNA, mRNA, or tRNA hydroxylation, cleavage at abasic (AP) sites in DNA, as well as ...
Tina A. Müller, Sarah L. Struble, Katheryn Meek, Robert P. Hausinger   +3 more
openaire   +3 more sources