Results 201 to 210 of about 110,461 (301)

Fluorinated Iminosugar Glycomimetics: Synthesis and Activity as GCase Ligands

European Journal of Organic Chemistry, EarlyView.
DAST‐mediated deoxyfluorination of suitably functionalized piperidines provided regio‐ and stereoselective access to fluorinated piperidine and pyrrolidine glycomimetics, the latter arising from an unusual ring‐contraction process. Fluorination generally enhanced β‐glucocerebrosidase (GCase) inhibitory potency, but lost PC activity toward L444P/L444P ...
Francesca Mangiavacchi, Alessio Morano, Cosimo Margheri, Cristina Faggi, Amelia Morrone, Camilla Matassini, Francesca Clemente, Andrea Goti, Martina Cacciarini, Francesca Cardona   +9 more
wiley   +1 more source

Radical-Mediated C3-Alkylation of Coumarins: A Comprehensive Review. [PDF]

ACS Omega
Caiuby CAD, Vasconcelos AS, Ferreira MAB.   +2 more
europepmc   +1 more source

Carbon‐Supported Catalytic Systems Assembled by π–π Interactions

European Journal of Organic Chemistry, EarlyView.
This review explores the noncovalent immobilization of organic and organometallic catalysts on carbonaceous supports through π–π interactions, highlighting its potential to enhance catalyst recovery, recyclability, and the sustainability of organic synthesis.
Chloé Jamalkhan, Léa Ibos, Sarah Bouery, Veronika Myronova, Anaïs Scuiller, Mohamed Mellah, David Kreher, Emmanuelle Schulz, Olivier R. P. David   +8 more
wiley   +1 more source

3-Azetidinylpiperidine-4-alkylidenemalononitrile and Related Building Blocks. [PDF]

Org Lett
Sanfiel JM, McCabe AT, Nilova A, Graf SL, Boyn JN, Grenning AJ.   +5 more
europepmc   +1 more source

MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih, Issam Tout, Najwa Ahmad Doha, Tala Abu Arja, Idris Mohammed, Doua Abdelrhaman, Waseem Hasan, Chadi Saad, Hamdi Mbarek, Borbala Mifsud, Sahar Isa Da'as   +10 more
wiley   +1 more source

Total Synthesis of (±)-Stemocurtisine via Catalytic Carbonylation. [PDF]

J Am Chem Soc
Zhang M, Yu H, Huang X, Dai M.
europepmc   +1 more source

Specific peptide enrichment strategies for neuropsychiatric disorders: From material design to diagnostic applications

Interdisciplinary Medicine, EarlyView.
This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang, Yejiao Shi, Minghui Guo, Yang Huang, Yirong Wang, Leping Huang, Helena S. Azevedo, Honggang Hu, Xin Dong   +8 more
wiley   +1 more source

Formal Markovnikov Hydroazolation of Alkenes via Reductive Activation of Alkylthianthrenium Salts. [PDF]

J Am Chem Soc
Matthews AD, Lorenz JR, Wickens ZK.
europepmc   +1 more source

Dual Genotoxic and Antigenotoxic Effects of 3‐Benzoylcoumarins in Mammalian Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are phenolic compounds widely recognized for their diverse pharmacological activities and have attracted increasing attention as potential chemopreventive agents. In the present study, four known 3‐benzoylcoumarin derivatives [(1), (2), (3), and (4)] were evaluated for their cytotoxic, mutagenic, and antigenotoxic effects in Chinese ...
Leticia Helena Parreira, Evelyn Pinheiro de Mendonça, Aléxia Polo Siqueira, Cleydson Finotti Cordeiro, Elkin José Torres Sierra, Rudy Bonfilio, Diogo Teixeira Carvalho, Pollyanna Francielli de Oliveira   +7 more
wiley   +1 more source