Results 171 to 180 of about 4,043,885 (307)

Understanding Mid-Life and Older Age Mortality Declines: Evidence from Union Army Veterans [PDF]

During the twentieth century the 17 year survival rate of 50-64 year old men rose by 24 percentage points. I examine waiting time until death from all natural causes and from all chronic, all acute, respiratory, stomach, infectious, all heart, ischemic ...
Dora L. Costa
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Coronary artery calcium and cystatin C for risk stratification of MACCEs and all-cause death in symptomatic patients. [PDF]

Clin Cardiol, 2023
Luo F, Luo JY, Liu F, Qiu YJ, Tian XX, Zeng L, Zhang ZR, Li XM, Yang YN.   +8 more
europepmc   +1 more source

Mental disorders predicted all cause and cause specific deaths in Finnish adults [PDF]

Evidence Based Mental Health, 2002
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Inflammatory and vascular biomarkers as predictors of all-cause death and cardiovascular outcomes in an Australian community-based cohort. [PDF]

Physiol Rep
Lee S, Castley A, Knuiman M, Nolan D, Sanfilippo F, Dwivedi G.   +5 more
europepmc   +1 more source

Effect of baseline resting heart rate on the risk of all-cause death in Chinese patients with hypertension. [PDF]

J Clin Hypertens (Greenwich), 2022
Yulong X, Fangfang F, Ya H, Yaping W, Meiqing H, Yan Z, Jianping L, Lishun L, Jing Z, Yong H.   +9 more
europepmc   +1 more source

Following cancer prevention guidelines may lower risk of death from all causes [PDF]

Cancer, 2011
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Association of growth differentiation factor-15 with renal disease outcomes and all-cause death in type 1 and type 2 diabetic patients: a meta-analysis. [PDF]

BMC Nephrol
Huang X, Yu N, Yu H, Yang S.
europepmc   +1 more source