Results 201 to 210 of about 4,043,885 (307)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Relationship between serum ferritin and the risk of all-cause death in patients with coronary artery disease. [PDF]

Clinics (Sao Paulo)
Jiang ZH, Lyu MM, Feng YJ, Wu TT, Pan Y, Deng CJ, Yang Y, Guo XX, Zheng YY, Xie X.   +9 more
europepmc   +1 more source

Association of shift work and dietary inflammatory potential with all-cause death among us hypertensive population: national health and nutrition examination study, 2005-2010. [PDF]

BMC Public Health, 2023
Li Y, Peng X, Wang X, Lin R, Liu X, Meng F, Liu X, Li L, Bai R, Wen S, Ruan Y, Tang R, Liu N.   +12 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Baseline and changes in prognostic nutritional index associate with heart failure hospitalization and all-cause death in patients with cardiac pacemaker. [PDF]

BMC Cardiovasc Disord
Zhang J, Yao H, Lu Y, Lian L, Zheng R, Chen C.   +5 more
europepmc   +1 more source

Associations of blood pressure components with risks of cardiovascular events and all-cause death in a Chinese population: A Prospective Study. [PDF]

J Clin Hypertens (Greenwich), 2022
Zhang Z, Gu X, Tang Z, Guan S, Liu H, Wu X, Zhao Y, Fang X.   +7 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Effects of RAS and SGLT2 inhibitors alone or in combination on end-stage kidney disease and/or all-cause death in patients with both diabetes and hypertension: a nationwide cohort study. [PDF]

Cardiovasc Diabetol
Hong S, Han K, Kim KS, Park CY.
europepmc   +1 more source

Author Correction: Effect of metabolic health and obesity on all-cause death and CVD incidence in Korean adults: a retrospective cohort study. [PDF]

Sci Rep, 2023
Kim YS, Shin SJ, Kim Y, Kim J, Kang HT.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source