Results 81 to 90 of about 16,607,172 (291)

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

PROPULSION SYSTEM DESIGN OF A YACHT CATAMARAN: COMPARISONS BETWEEN CONVENTIONAL AND DIFFERENT DIESEL-ELECTRIC SOLUTIONS

, 2012
both designers and builders are engaged in a very demanding challenge: finding competitive solutions both for the first cost and for the subsequent management and maintenance costs.
MARINO', ALBERTO, BOSICH, DANIELE, BUCCI, VITTORIO, SULLIGOI, GIORGIO   +3 more
core  

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

European Student Moon Orbiter solar electric propulsion subsystem architecture: an all–electric spacecraft

, 2007
This paper presents the Phase A study of the Solar Electric Propulsion subsystem selected for the ESA European Student Moon Orbiter enhanced microsatellite, performed at QinetiQ under ESA funding.
Wallace, Neil, Grubisic, Angelo, Coletti, Michele, Wells, Nigel   +3 more
core   +1 more source

Naval Smart Grid Preliminary Integration onboard Electric Ships

, 2021
Innovation in platform systems, as well as requirements on energy efficiency, are pushing towards the naval vessels' electrification. In fact, the power required by new platform systems, sensors, and new subsystems (for supporting the latter) is so big ...
Vittorio Bucci, Bucci, Vittorio, Paolo Borghese, Vicenzutti, Andrea, Serena Bertagna, Andrea Vicenzutti, Sulligoi, Giorgio, Cataneo, Michele, Michele Cataneo, Bertagna, Serena, Borghese, Paolo, Giorgio Sulligoi   +11 more
core   +1 more source

A Scalable Droplet Microfluidic Platform That Overcomes Large‐Cell Constraints for Long‐Term Plant Cell Culture and Embryogenesis Analysis

Advanced Science, EarlyView.
This work presents a large‐cell‐compatible droplet microfluidic platform that overcomes long‐standing barriers in plant cell culture by enabling high‐fidelity encapsulation, novel multilayer 3D droplet incubation for scalable long‐term culture, and support for the full developmental progression of large plant cells.
Arman Mirmiran, Fangchi Shao, Gregory Datto, Tathansh Joshi, Elizabeth Chatt, Yashar Bashirzadeh, Dan Stessman, Lai Wei, Kuangwen Hsieh, Hena Guo, Tza‐Huei Wang   +10 more
wiley   +1 more source

Smart Shipboard Power System Operation and Management

Inventions, 2016
During recent years, optimal electrification of isolated offshore systems has become increasingly important and received extensive attention from the maritime industry.
Fotis D. Kanellos, Amjad Anvari-Moghaddam, Josep M. Guerrero   +2 more
doaj   +1 more source

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

A Mixed-Integer Linear Programming Framework for Optimal Scheduling of Maritime Mobile Energy Storage

Mathematics
The offshore wind energy sector requires efficient logistics to retrieve generated electricity using maritime mobile energy storage systems. This study addresses the maritime mobile energy storage scheduling problem to maximise the total net energy ...
Yunxiang Shu, Yu Guo, Yuquan Du, Shuaian Wang   +3 more
doaj   +1 more source

Self‐Responsive Plastron Maintenance on a Superhydrophobic Mesh via Locally Integrated Electrolysis

Advanced Science, EarlyView.
This work presents a self‐switchable SHM‐E surface that enables rapid, autonomous plastron self‐repair and long‐term stability. Plastron loss triggers circuit closure and localized electrolysis, while capillary spreading rapidly restores a continuous plastron and self‐terminates the current.
Jiaming Wang, Zhen Zhang, Yuhong Liu
wiley   +1 more source