Results 41 to 50 of about 91,855 (262)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Identification of broken conductor faults in interconnected transmission systems based on discrete wavelet transform.

PLoS ONE
Interconnected transmission systems are increasingly spreading out in HV networks to enhance system efficiency, decrease reserve capacity, and improve service reliability.
Basem Abd-Elhamed Rashad, Doaa K Ibrahim, Mahmoud I Gilany, Ahmed Sayed Abdelhamid, Wael Abdelfattah   +4 more
doaj   +1 more source

Fault location for MMC–MTDC transmission lines based on least squares-support vector regression

The Journal of Engineering, 2019
The dc transmission line protection plays a crucial role in the secure operation of a multi-terminal modular-multilevel-converter-based high-voltage direct current (MMC–MTDC) system, which is increasingly adopted as a promising option in the power ...
Mingguang Zhang, Heng Wang
doaj   +1 more source

Deployment Strategies for Large Intelligent Surfaces

IEEE Access, 2022
Beyond 5G communication systems must be able to meet the requirements imposed by the ever-increasing demand in capacity, while guaranteeing robustness, reliability, low latency, security, as well as spectral and power efficiencies.
Andreia Pereira, Fredrik Rusek, Marco Gomes, Rui Dinis   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Reliability Analysis of Emergency Message Broadcast at an Intersection in 2-D VANET

Dianxin kexue, 2014
Reliability is an important issue for emergency message broadcast services in vehicular Ad Hoc network （VANET）. Most investigations of such broadcast in VANET focus on multi-hop connectivity, taking all one-hop links for granted.
Enzhan Zhang, Yujun Kuang
doaj   +2 more sources

A Randomized Fully Polynomial Time Approximation Scheme for the All-Terminal Network Reliability Problem [PDF]

SIAM Journal on Computing, 1995
Summary: The classic all-terminal network reliability problem posits a graph, each of whose edges fails independently with some given probability. The goal is to determine the probability that the network becomes disconnected due to edge failures. This problem has obvious applications in the design of communication networks. Since the problem is \(\# {\
openaire   +2 more sources