Results 11 to 20 of about 1,526 (171)
Enzymes and cellular interplay required for flux of fixed nitrogen to ureides in bean nodules. [PDF]
Nat Commun, 2022 Tropical legumes transport fixed nitrogen in form of ureides (allantoin and allantoate) over long distances from the nodules to the shoot. Ureides are formed in nodules from purine mononucleotides by a partially unknown reaction network that involves ...
Voß L +4 more
europepmc +4 more sources
Harnessing natural diversity to probe metabolic pathways. [PDF]
PLoS Genetics, 2005 Analyses of cellular processes in the yeast Saccharomyces cerevisiae rely primarily upon a small number of highly domesticated laboratory strains, leaving the extensive natural genetic diversity of the model organism largely unexplored and unexploited ...
Oliver R Homann +3 more
doaj +2 more sources
Elucidating the Neuroprotective Mechanisms of G-3702 in Ischemic Stroke via Integrated Metabolomics and Computational Approaches. [PDF]
CNS Neurosci TherG‐3702, a structural analog of NBP, improves neurological outcomes in ischemic stroke mice by promoting angiogenesis primarily through the Avb3 integrin pathway. Integrated metabolomics, transcriptomics, and machine learning analyses reveal key therapeutic targets and biomarkers, advancing our understanding of proangiogenic treatments for stroke and ...
Wang C, Zhang F, Zheng Q, Wang J.
europepmc +2 more sources
Red Blood Cell Metabolism in Patients with Propionic Acidemia
Separations, 2021 Propionic acidemia (PA) is a rare autosomal recessive disorder with an estimated incidence of 1:100,000 live births in the general population. Due in part to an insufficient understanding of the disease’s pathophysiology, PA is often associated with ...
Micaela Kalani Roy +5 more
doaj +1 more source
Combined genomics to discover genes associated with tolerance to soil carbonate
Plant, Cell &Environment, Volume 46, Issue 12, Page 3986-3998, December 2023., 2023 Abstract Carbonate‐rich soils limit plant performance and crop production. Previously, local adaptation to carbonated soils was detected in wild Arabidopsis thaliana accessions, allowing the selection of two demes with contrasting phenotypes: A1 (carbonate tolerant, c+) and T6 (carbonate sensitive, c−).
Silvia Busoms +7 more
wiley +1 more source
Allantoate transport in Saccharomyces cerevisiae [PDF]
Journal of Bacteriology, 1979 Allantoate uptake appears to be mediated by an energy-dependent active transport system with an apparent Michaelis constant of about 50 microM. Cells were able to accumulate allantoate to greater than 3,000 times the extracellular concentration. The rate of accumulation was maximum at pH 5.7 to 5.8.
V, Turoscy, T G, Cooper
openaire +2 more sources
New Phytologist, Volume 240, Issue 2, Page 744-756, October 2023., 2023 Summary Nitrogen‐fixing symbioses allow legumes to thrive in nitrogen‐poor soils at the cost of diverting some photoassimilate to their microsymbionts. Effort is being made to bioengineer nitrogen fixation into nonleguminous crops. This requires a quantitative understanding of its energetic costs and the links between metabolic variations and symbiotic
Bethany L. Holland +5 more
wiley +1 more source
The Plant Genome, Volume 16, Issue 2, June 2023., 2023 Abstract De novo purine biosynthesis is required for the incorporation of fixed nitrogen in ureide exporting nodules, as formed on soybean [Glycine max (L.) Merr.] roots. However, in many cases, the enzymes involved in this pathway have been deduced strictly from genome annotations with little direct genetic evidence, such as mutant studies, to confirm
Cuong X. Nguyen +5 more
wiley +1 more source
Inhibition of rhizobial cheaters by the host Medicago truncatula involves repression of symbiotic functions and induction of defense. [PDF]
New PhytolSummary In symbiotic plant–microbe interactions, the host invests considerable amounts of resources in the microbial partner. If the microbe does not reciprocate with a comparable symbiotic benefit, it is regarded as a cheater. The host responds to cheaters with negative feedback mechanisms (sanctions) to prevent fitness deficits resulting from being ...
Chen M +8 more
europepmc +2 more sources
TRUEE; a bioinformatic pipeline to define the functional microRNA targetome of Arabidopsis
The Plant Journal, Volume 110, Issue 5, Page 1476-1492, June 2022., 2022 SUMMARY Central to plant microRNA (miRNA) biology is the identification of functional miRNA‐target interactions (MTIs). However, the complementarity basis of bioinformatic target prediction results in mostly false positives, and the degree of complementarity does not equate with regulation. Here, we develop a bioinformatic workflow named TRUEE (Targets
Gigi Y. Wong, Anthony A. Millar
wiley +1 more source