Results 151 to 160 of about 86,674 (251)

Prevalence of apolipoprotein E epsilon4 allele may explain the geographical variation of coronary heart disease mortality rates in Western Europe [PDF]

, 2010
William B. Grant
openalex   +1 more source

ADGRG1 wt Allele [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

High‐Resolution Genomic Resources for Trait Mapping and Precision Breeding for Adzuki Bean (Vigna angularis)

Advanced Science, EarlyView.
This study establishes crucial genomic resources for adzuki bean, including a reference genome, variation map, and the AdzukiBeanAtlas toolkit. We identify key candidate genes (ANKRD50, NAC73, ANR1, NPF5.4) for important agronomic traits through Genome‐Wide Association Studies (GWAS).
Liangliang Hu, Xiaolei Wang, Yazhou Zhang, Vanika Garg, Xingxing Yuan, Renfeng Xue, Hongmei Zhou, Yanhua Chen, Weili Hu, Rutwik Barmukh, Rong Cao, Tianxiao Chen, Qiannan Song, Dan Gao, Gaoling Luo, Xu Zhu, Xin Jing, Suhua Wang, Caiju Li, Yunshan Wei, Weide Ge, Xin Chen, Lixia Wang, Rajeev K Varshney, Chengzhi Jiao, Xuzhen Cheng, Honglin Chen   +26 more
wiley   +1 more source

RB1 wt Allele [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

U‐Shaped Response of Flowering Time to Low and High Nitrogen via a Transcription Feedback Loop in Rice

Advanced Science, EarlyView.
The “seesaw effect” of Nhd1‐Ghd7 module in regulating flowering time (days to heading in rice) responses to nitrogen (N) via Hd3a/RFT1: deficient‐N (DN) delays flowering via Ghd7‐mediated suppression of Nhd1; moderate‐N (MN) impairs this suppression, enhancing Nhd1 to promote flowering; whereas superior‐N (SN) delays flowering by Nhd1‐activated ...
Shunan Zhang, Guanzhong Shou, Xianping Li, Xuemin Song, Xuesong Li, Junjie Guo, Jiaqiang Lu, Yi Jin, Hongye Qu, Ming Yan, Wona Ding, Ying Liu, Guohua Xu   +12 more
wiley   +1 more source

Moderate–severe beta‐thalassemia intermedia phenotype caused by sextuplicated alpha‐globin gene allele in two beta‐thalassemia carriers [PDF]

Ahlem Achour, Jeroen Knijnenburg, Tamara T. Koopmann, Aviad E. Raz, Marc Tischkowitz, Thomas D. Coates, Frank Baas, Cornelis L. Harteveld   +7 more
openalex   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source