Results 231 to 240 of about 1,408,208 (397)

Pan‐Variant SARS‐CoV‐2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes

Advanced Science, EarlyView.
An integrative approach identifies conserved B‐cell and T‐cell epitopes within SARS‐CoV‐2 proteins, redirecting immune responses from variable to conserved regions. These epitopes elicit robust humoral and cellular immunity, neutralizing diverse viral variants. Promiscuous T‐cell epitopes demonstrate cross‐species efficacy, highlighting their potential
Masaud Shah, Sung Ung Moon, Ji‐Yon Shin, Ji‐Hye Choi, Doyoon Kim, Hyun Goo Woo   +5 more
wiley   +1 more source

Evidence for a New Allele in the Kidd Blood Group System in Indians of Northern Mato Grosso, Brazil [PDF]

, 1960
Richard T. Silver, Jane M. Haber, Aaron Kellner   +2 more
openalex   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

On the Nature of Incompatibility Alleles in Taraxacum elatum^|^times;T. longe-appendiculatum

, 1956
Sakuichi Okabe
openalex   +2 more sources

INCREMENT OF AVERAGE FITNESS FOR MULTIPLE ALLELES [PDF]

, 1969
C. C. Li
openalex   +1 more source

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

Nature Neuroscience, 2012
T. Klengel, D. Mehta, C. Anacker, M. Rex-Haffner, J. Pruessner, C. Pariante, Thaddeus W. W. Pace, Kristina B. Mercer, H. Mayberg, B. Bradley, C. Nemeroff, F. Holsboer, Christine Marcelle Heim, K. Ressler, T. Rein, E. Binder   +15 more
semanticscholar   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

A rare homozygous missense GDF2 (BMP9) mutation causing PAH in siblings: Does BMP10 status contribute?

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 228-233, January 2023., 2023
Abstract Pulmonary arterial hypertension (PAH) is a disease characterized by pathological remodeling of the pulmonary vasculature causing elevated pulmonary artery pressures and ultimately, right ventricular failure from chronic pressure overload. Heterozygous pathogenic GDF2 (encoding bone morphogenetic protein 9 (BMP9)) variants account for some (>1%)
Paul Upton, Susan Richards, Angela Bates, Karen Y. Niederhoffer, Nicholas W. Morrell, Susan Christian   +5 more
wiley   +1 more source

Landscape of rare-allele variants in cultivated and wild soybean genomes. [PDF]

Plant Genome
Liu Z, Shi X, Yang Q, Li Y, Yang C, Zhang M, An YC, Nguyen HT, Yan L, Song Q.   +9 more
europepmc   +1 more source

THE BEHAVIOR OF LYCOPERSICON INCOMPATIBILITY ALLELES IN AN ALIEN GENETIC MILIEU

, 1968
Franklin W. Martin
openalex   +2 more sources