Results 281 to 290 of about 1,186,851 (331)

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

Human Leukocyte Antigen (<i>HLA</i>) Signatures and Idiosyncratic Drug-Induced Liver Injury. [PDF]

Int J Mol Sci
Onaciu A, Grama A, Agoșton Ș, Mititelu A, Mariş B, Ştefănescu H, Pop TL.   +6 more
europepmc   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Early life-stage thermal resilience is determined by climate-linked regulatory variation. [PDF]

Proc Natl Acad Sci U S A
Nunez JCB, Tangwancharoen S, Finnegan KM, Bufferd EM, King OC, Proud LA, Lockwood BL.   +6 more
europepmc   +1 more source

The rs713586 risk variant dysregulates ADCY3 rather than DNAJC27, leading to obesity through ZFP42-TET1-mediated DNA methylation. [PDF]

EBioMedicine
Wang W, Liu Y, Dong S, Wu X, Zhang F, Wang X, Zhang X, Hu X, Wang Z.   +8 more
europepmc   +1 more source

Association of the rs2814778 variant in the ACKR1 gene, responsible for the Duffy erythrocyte antigen "null" phenotype, with COVID-19 severity in Southern Brazil. [PDF]

Einstein (Sao Paulo)
Góis KS, Braga M, Souza VH, Schavaren J, Grava S, Simão ANC, Visentainer JEL, Lima Neto QA.   +7 more
europepmc   +1 more source

The Branching Process: A General Conceptual Framework for Addressing Current Ecological and Evolutionary Questions. [PDF]

Life (Basel)
Xia X.
europepmc   +1 more source

Association of Gene Expression Alterations with Aggressive Features in Papillary Thyroid Carcinomas Harboring Low Allele Frequency BRAF V600E Mutations. [PDF]

J Otolaryngol Head Neck Surg
Katz A, Lefebvre C, Bandargal S, Forest VI, Pusztaszeri MP, Payne RJ.   +5 more
europepmc   +1 more source

Common Genetic Variants in <i>TRIO</i> Are Associated With Autism in Chinese Han Population. [PDF]

Genet Res (Camb)
Shen H, Sun X, Wang Z, Jiang M, Wang J, Lu T, Yue W, Zhang D, Wang L, Li J.   +9 more
europepmc   +1 more source

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Allelic Exchange

2014
Methods used to understand the function of a gene/protein are one of the hallmarks of modern molecular genetics. The ability to genetically manipulate bacteria has become a fundamental tool in studying these organisms and while basic cloning has become a routine task in molecular biology laboratories, generating directed mutations can be a daunting ...
McKenzie K, Lehman, Jeffrey L, Bose, Kenneth W, Bayles   +2 more
openaire   +2 more sources