Results 361 to 370 of about 1,408,208 (397)
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Allelic histories: positive selection on a HIV-resistance allele
Trends in Ecology & Evolution, 2004The CCR5-Delta32 allele crucially determines the course of HIV infection and appears to be highly protective against the disease. Population genetic studies suggest that the allele has been under positive selection in Europe in the past. In a recent paper, Alison Galvani and Montgomery Slatkin collate the available evidence and use a mathematical model
Hilde Wilkinson-Herbots +1 more
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The use marker alleles for the introgression of linked quantitative alleles
Theoretical and Applied Genetics, 1977It is shown that when an exotic strain and a commercial strain differ genetically at a quantitative locus and at an adjoining marker locus, repeated backcrosses to the commercial strain, retaining only backcross progeny carrying the exotic marker allele, will allow the effective introgression of the linked quantitative allele from the exotic to the ...
J. Plotkin-Hazan, M. Soller
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Frequency of Gc Alleles and a Variant Gc Allele in Iceland
Human Heredity, 1980The gene frequency for Gc1 and Gc2 in an Icelandic population was found to be 0.71 and 0.29, respectively. An electrophoretic variant similar to Gc Norway was detected in 5 individuals of the same family. A pedigree of 14 family members, including two spouses, is presented.
Gudmundur Thordarson +3 more
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2014
Methods used to understand the function of a gene/protein are one of the hallmarks of modern molecular genetics. The ability to genetically manipulate bacteria has become a fundamental tool in studying these organisms and while basic cloning has become a routine task in molecular biology laboratories, generating directed mutations can be a daunting ...
McKenzie K, Lehman +2 more
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Methods used to understand the function of a gene/protein are one of the hallmarks of modern molecular genetics. The ability to genetically manipulate bacteria has become a fundamental tool in studying these organisms and while basic cloning has become a routine task in molecular biology laboratories, generating directed mutations can be a daunting ...
McKenzie K, Lehman +2 more
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Prevalence of the amyloidogenic transthyretin (TTR) V122I allele in 14 333 African–Americans
Amyloid: Journal of Protein Folding Disorders, 2015Background: Transthyretin (TTR) V122I (rs76992529) is one of 111 variants caused by point mutations in the coding sequence of the human TTR gene that are associated with systemic amyloidosis.
D. Jacobson +3 more
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Theoretical Population Biology, 2001
A subpopulation D of rare alleles is considered. The subpopulation is part of a large population that evolves according to a Moran model with selection and growth. Conditional on the current frequency, q, of the rare allele, an approximation to the distribution of the genealogy of D is derived.
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A subpopulation D of rare alleles is considered. The subpopulation is part of a large population that evolves according to a Moran model with selection and growth. Conditional on the current frequency, q, of the rare allele, an approximation to the distribution of the genealogy of D is derived.
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, 1998
Identifying recently bottlenecked populations (populations severely reduced in size) is important because bottlenecks can increase demographic stochasticity, rate of inbreeding, loss of genetic variation, and fixation of deleterious alleles and, thereby,
G. Luikart, J. Cornuet
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Identifying recently bottlenecked populations (populations severely reduced in size) is important because bottlenecks can increase demographic stochasticity, rate of inbreeding, loss of genetic variation, and fixation of deleterious alleles and, thereby,
G. Luikart, J. Cornuet
semanticscholar +1 more source
Nature, 1958
THE genetic systems of self-incompatibility among the homomorphic flowering plants have been broadly subdivided into two groups1: (1) ‘gametophytic systems’ in which the pollen reaction is determined by the S allele contained in the pollen (Leguminosae, Scrophulariaceae, Solanaceae, Gramineae) and (2) ‘sporophytic systems’ in which the pollen reaction ...
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THE genetic systems of self-incompatibility among the homomorphic flowering plants have been broadly subdivided into two groups1: (1) ‘gametophytic systems’ in which the pollen reaction is determined by the S allele contained in the pollen (Leguminosae, Scrophulariaceae, Solanaceae, Gramineae) and (2) ‘sporophytic systems’ in which the pollen reaction ...
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The distribution of rare alleles
Journal of Mathematical Biology, 1995Population geneticists have long been interested in the behavior of rare variants. The definition of a rare variant has been the subject of some debate, centered mainly on whether alleles with small relative frequency should be considered rare, or whether alleles with small numbers should be.
Simon Tavaré, Paul Joyce
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