Results 41 to 50 of about 5,564,836 (365)

Inference of historical population-size changes with allele-frequency data

, 2020
With up to millions of nearly neutral polymorphisms now being routinely sampled in population-genomic surveys, it is possible to estimate the site-frequency spectrum of such sites with high precision.
Haubold, B., Lynch, M., Maruki, T., Pfaffelhuber, P.   +3 more
core   +1 more source

Estimating the genome-wide contribution of selection to temporal allele frequency change

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance A long-standing problem in evolutionary biology is to understand the processes that shape the genetic composition of populations. In a population without migration, two processes that change allele frequencies are selection, which increases ...
Vince Buffalo, G. Coop
semanticscholar   +1 more source

Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population

BMC Medical Genetics, 2018
Background Rheumatic heart disease (RHD) is an autoimmune disease triggered by acute rheumatic fever (ARF). Matrix metalloproteinases (MMPs) play an important role in the modulation of immune responses.
Wei Hu, Yujia Ye, Yirui Yin, Peng Sang, Linhua Li, Jing Wang, Wen Wan, Rui Li, Xiangfeng Bai, Yuehui Xie, Zhaohui Meng   +10 more
doaj   +1 more source

The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa [PDF]

, 2016
Transthyretin (TTR) pV142I (rs76992529-A) is one of the 113 variants in the human TTR gene associated with systemic amyloidosis. It results from a G to A transition at a CG dinucleotide in the codon for amino acid 122 of the mature protein (TTR V122I ...
Alexander, Alice A, Buxbaum, Joel N., Garvey, W. T, Jacobson, Daniel R, Kalidi, Issa, Modiano, David, Sirima, Sodiomon B, Tagoe, Clement, Tishkoff, Sara, Toure, Amadou, Williams, Scott M   +10 more
core   +1 more source

GADMA: Genetic algorithm for inferring demographic history of multiple populations from allele frequency spectrum data

bioRxiv, 2018
During the last few years more and more genomic analysis of individuals of closely related species has appeared. The history of evolution and development of populations, so-called demographic history, is embedded into their genome and we can try to pull ...
E. Noskova, V. Ulyantsev, Klaus‐Peter Koepfli, S. O’Brien, P. Dobrynin   +4 more
semanticscholar   +1 more source

Evidence for selection on SARS-CoV-2 RNA translation revealed by the evolutionary dynamics of mutations in UTRs and CDSs

RNA Biology, 2022
RNA translation is the rate-limiting step when cells synthesize proteins. Elevating translation efficiency (TE) is intuitively beneficial. Particularly, when viruses invade host cells, how to compete with endogenous RNAs for efficient translation is a ...
Lin Zhu, Qi Wang, Weiyu Zhang, Hao Hu, Kexin Xu   +4 more
doaj   +1 more source

The effect of recurrent mutations on genetic diversity in a large population of varying size [PDF]

, 2016
Recurrent mutations are a common phenomenon in population genetics. They may be at the origin of the fixation of a new genotype, if they give a phenotypic advantage to the carriers of the new mutation.
Smadi, Charline
core   +3 more sources

A Population Study: HLA-A, -B, -C, -DRB1, -DQB1, -DQA1 Alleles, and ABDR Haplotype Frequencies in the Aegean Region of Türkiye

Forbes Tıp Dergisi
Objective: Human leukocyte anti-gen (HLA) molecules are vital molecules because they present foreign anti-gens to immune cells and trigger the immune response.
Aslı ÖZKIZILCIK KOÇYİĞİT, Tülay KILIÇASLAN AYNA, Mustafa SOYÖZ, Burcu ÇERÇİ ALKAÇ, Rasime Derya GÜLEÇ, Deniz İlhan TOPÇU, İbrahim PİRİM   +6 more
doaj   +1 more source

Genetic diversity through human leukocyte antigen typing in end-stage renal disease patients and prospective donors of North India

Indian Journal of Pathology and Microbiology, 2016
As the incidence of end-stage renal disease (ESRD) is rapidly increasing, the demand for dialysis and transplantation has dramatically increased, which has led to concerns about the availability and equitable allocation of kidneys for transplantation ...
Mohit Chowdhry, Raj Nath Makroo, Manoj Kumar   +2 more
doaj   +1 more source

Use of Microsatellites in Genetic Diversity Assessment, Parentage Testing and Individual Identification of the Kangal Shepherd Dog

Acta Veterinaria, 2020
The Kangal Shepherd Dog is considered the most common dog breed of Turkish origin. This study investigated variations in ten autosomal microsatellite markers (PEZ01, PEZ03, PEZ05, PEZ06, PEZ08, PEZ12, PEZ20, FHC2010, FHC2054 and FHC2079) for the purposes
Vladimir Dimitrijević, Marko Ristanić, Ljubodrag Stanisić, Darko Drobnjak, Milivoje Urosević, Umit Ozkanal, Zoran Stanimirović   +6 more
doaj   +1 more source