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Exact Solution of the Multi-Allelic Diffusion Model [PDF]
Mathematical Biosciences (2007) v209 pp124-70, 2005 We give an exact solution to the Kolmogorov equation describing genetic drift for an arbitrary number of alleles at a given locus. This is achieved by finding a change of variable which makes the equation separable, and therefore reduces the problem with an arbitrary number of alleles to the solution of a set of equations that are essentially no more ...
Baxter, G., Blythe, R. A., McKane, A. J.
arxiv +4 more sources
Borrowed alleles and convergence in serpentine adaptation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 ACKNOWLEDGMENTS. We thank members of the L.Y. and K.B. laboratories for helpful discussions. This work was supported through the European Research Council Grant StG CA629F04E (to L.Y.); a Harvard University Milton Fund Award (to K.B.); Ruth L ...
Arnold, Brian J. +7 more
core +3 more sources
The Effect of Recombination on the Speed of Evolution [PDF]
, 2019 It has been a puzzling question why some organisms reproduce sexually. Fisher and Muller hypothesized that reproducing by sex can speed up the evolution. They explained that in the sexual reproduction, recombination can combine beneficial alleles that lie on different chromosomes, which speeds up the time that those beneficial alleles spread to the ...
Udomchatpitak, Nantawat
arxiv +5 more sources
Stability and response of polygenic traits to stabilizing selection and mutation [PDF]
arXiv, 2014 When polygenic traits are under stabilizing selection, many different combinations of alleles allow close adaptation to the optimum. If alleles have equal effects, all combinations that result in the same deviation from the optimum are equivalent. Furthermore, the genetic variance that is maintained by mutation-selection balance is $2 \mu/S$ per locus,
Barton +8 more
arxiv +3 more sources
Epitope prediction improved by multitask support vector machines [PDF]
We use various multitask kernels in order to improve MHC-I-peptide
binding prediction, in particular for MHC alleles for which few training data
is available. (05/02/2007), 2007 Motivation: In silico methods for the prediction of antigenic peptides binding to MHC class I molecules play an increasingly important role in the identification of T-cell epitopes. Statistical and machine learning methods, in particular, are widely used to score candidate epitopes based on their similarity with known epitopes and non epitopes.
Jacob, Laurent, Vert, Jean-Philippe
arxiv +3 more sources
Association between Q192R Polymorphism of Paraoxonase-1 Gene and Risk of Coronary Artery Disease: A Case-control Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Coronary Artery Disease (CAD) is a complex metabolic disorder in which lifestyle and genetic factors are known to play key roles in pathogenesis.
Harleen Kaur +4 more
doaj +1 more source
Frontiers in Immunology, 2021 The KIR (killer-cell immunoglobulin-like receptor) region is characterized by structural variation and high sequence similarity among genes, imposing technical difficulties for analysis.
Leonardo M. Amorim +13 more
doaj +1 more source
Genotypic stratification of risk of acute cerebral circulation disorder
КардиоСоматика, 2021 Aim. To study the association of rs662799 gene APOA5 with the development of Acute Cerebrovascular Event in patients with cardiovascular diseases (CVD) and their risk factors. Material and methods. 260 Acute Cerebrovascular Event patients (main group)
Dmitriy A. Nikulin +4 more
doaj +1 more source
Beta-lactoglobulin (BLG) gene polymorphism in Ukrainian and foreign cows
Біологія тварин, 2021 The aim of the study was to study the polymorphism of the beta-lactoglobulin gene in cows of Ukrainian Red-Spotted dairy cattle and Montbéliarde breeds and animals obtained by crossing the local Ukrainian Red-Spotted dairy cattle with bulls of ...
I. Mitioglo
doaj +1 more source
Frontiers in Immunology, 2020 AimSARS-CoV-2 infection is a world-wide public health problem. Several aspects of its pathogenesis and the related clinical consequences still need elucidation. In Italy, Sardinia has had very low numbers of infections.
Roberto Littera +38 more
doaj +1 more source