Results 91 to 100 of about 1,221,818 (402)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive [PDF]

Nucleic Acids Research, Oxford University Press, 2016, 44 (2), pp.621 - 635, 2018
Parental allele-specific expression of imprinted genes is mediated by imprinting control regions (ICRs) that are constitutively marked by DNA methylation imprints on the maternal or paternal allele. Mono-allelic DNA methylation is strictly required for the process of imprinting and has to be faithfully maintained during the entire lifespan.
arxiv   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

GPD1 and ADH3 Natural Variants Underlie Glycerol Yield Differences in Wine Fermentation

Frontiers in Microbiology, 2018
Glycerol is one of the most important by-products of alcohol fermentation, and depending on its concentration it can contribute to wine flavor intensity and aroma volatility.
Sebastián M. Tapia, Sebastián M. Tapia, Sebastián M. Tapia, Mara Cuevas, Valentina Abarca, Valentina Abarca, Verónica Delgado, Verónica Delgado, Vicente Rojas, Vicente Rojas, Verónica García, Verónica García, Claire Brice, Claudio Martínez, Claudio Martínez, Francisco Salinas, Francisco Salinas, Luis F. Larrondo, Luis F. Larrondo, Francisco A. Cubillos, Francisco A. Cubillos, Francisco A. Cubillos   +21 more
doaj   +1 more source

DNA-based S-genotyping of Japanese plum and pluot cultivars to clarify incompatibility relationships [PDF]

, 2007
Diploid japanese plum (Prunus salicina Lindl.) cultivars are commonly self-incompatible. To date, 14 incompatibility alleles (S-alleles) have been identified and labeled with alphabetical (S-a-S-n) and 5 with numeric codes (S-1, S-3-S-6).
Halász, Júlia, Hegedűs, Attila, Pedryc, Andrzej, Szabó, Zoltán   +3 more
core   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Variability of omp25 and omp2a Genes in Brucella Strains of Different Taxonomic Position

Проблемы особо опасных инфекций
The aim of the study was to identify structural differences in the Brucella omp25 and omp2a genes, which make it possible to determine their taxonomic position.Materials and methods.
N. A. Osina, E. G. Boolgakova, A. G. Osin, I. G. Shvidenko, S. A. Shcherbakova   +4 more
doaj   +1 more source

A powerful allele based test for case-control association studies [PDF]

arXiv, 2015
In a case-control study aimed at localizing disease variants, association between a marker and the disease status is often tested by comparing the marker allele frequencies among cases and controls. These marker allele frequencies are expected to be different if the marker is associated with the disease. The power of the commonly used allele based test
arxiv  

Prediction of deleterious human alleles.

Human Molecular Genetics, 2001
Single nucleotide polymorphisms (SNPs) constitute the bulk of human genetic variation, occurring with an average density of approximately 1/1000 nucleotides of a genotype.
S. Sunyaev, V. Ramensky, I. Koch, Warren C. Lathe, A. Kondrashov, P. Bork   +5 more
semanticscholar   +1 more source

Drosophila Cappuccino alleles provide insight into formin mechanism and role in oogenesis. [PDF]

, 2015
During Drosophila development, the formin actin nucleator Cappuccino (Capu) helps build a cytoplasmic actin mesh throughout the oocyte. Loss of Capu leads to female sterility, presumably because polarity determinants fail to localize properly in the ...
Bor, Batbileg, Quinlan, Margot E, Roth-Johnson, Elizabeth A, Yoo, Haneul   +3 more
core   +1 more source