Results 121 to 130 of about 1,221,818 (402)
MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song +11 morewiley +1 more sourceGENOTYPES AND PHENOTYPES OF ALZHEIMER’S DISEASE
Наука и инновации в медицине, 2018 Aim - research of gene APOE for definition of allele structures of the human population phenotypes resulting in risk of Alzheimer’s disease. Materials and methods. Use of the Hardy-Weinberg theory and statistical researches of the alleles distribution of AN N Volobuev, VF F Pyatin, NP P Romanchuk, NN N Aleksandrova +3 moredoaj +1 more sourceMutation supply and the repeatability of selection for antibiotic
resistance
, 2017 Whether evolution can be predicted is a key question in evolutionary biology.
Here we set out to better understand the repeatability of evolution. We
explored experimentally the effect of mutation supply and the strength of
selective pressure on the ...de Visser, J. Arjan G. M., Hwang, Sungmin, Krug, Joachim, van Dijk, Thomas, Zwart, Mark P. +4 morecore +1 more sourceA genome-wide scan for common alleles affecting risk for autism
Human Molecular Genetics, 2010 Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs).R. Anney, L. Klei, D. Pinto, R. Regan, J. Conroy, T. Magalhães, C. Correia, B. Abrahams, N. Sykes, A. Pagnamenta, J. Almeida, E. Bacchelli, A. Bailey, G. Baird, A. Battaglia, T. Berney, N. Bolshakova, S. Bölte, P. Bolton, T. Bourgeron, Sean Brennan, J. Brian, A. Carson, G. Casallo, J. Casey, S. Chu, L. Cochrane, Christina M. Corsello, Emily L. Crawford, Andrew Crossett, G. Dawson, M. D. de Jonge, R. Delorme, Irene Drmic, E. Duketis, F. Duque, A. Estes, Penny Farrar, B. Fernandez, S. Folstein, E. Fombonne, C. Freitag, J. Gilbert, C. Gillberg, J. Glessner, J. Goldberg, Jonathan Green, Stephen J. Guter, H. Hakonarson, E. Heron, M. Hill, R. Holt, J. Howe, G. Hughes, Vanessa Hus, R. Igliozzi, Cecilia Kim, S. Klauck, A. Kolevzon, Olena Korvatska, Vlad Kustanovich, C. Lajonchere, J. Lamb, Magdalena Laskawiec, M. Leboyer, A. Le Couteur, B. Leventhal, A. C. Lionel, Xiao-qing Liu, C. Lord, L. Lotspeich, Sabata C. Lund, E. Maestrini, W. Mahoney, Carine Mantoulan, C. Marshall, H. McConachie, C. McDougle, J. McGrath, W. McMahon, N. Melhem, Alison K. Merikangas, O. Migita, N. Minshew, G. Mirza, J. Munson, S. Nelson, Carolyn Noakes, A. Noor, G. Nygren, G. Oliveira, K. Papanikolaou, J. Parr, B. Parrini, T. Paton, A. Pickles, J. Piven, D. Posey, A. Poustka, F. Poustka, Aparna Prasad, J. Ragoussis, Katy Renshaw, Jessica Rickaby, W. Roberts, K. Roeder, B. Rogé, M. Rutter, L. Bierut, J. Rice, Jeff Salt, K. Sansom, Daisuke Sato, R. Segurado, Lili Senman, N. Shah, V. Sheffield, L. Soorya, I. Sousa, Vera Stoppioni, Christina P Strawbridge, R. Tancredi, K. Tansey, Bhooma Thiruvahindrapduram, A. Thompson, Susanne A. Thomson, A. Tryfon, J. Tsiantis, H. van Engeland, J. Vincent, F. Volkmar, S. Wallace, Kai Wang, Zhouzhi Wang, T. Wassink, Kirsty Wing, Kerstin Wittemeyer, Shawn Wood, B. Yaspan, Danielle M Zurawiecki, L. Zwaigenbaum, C. Betancur, J. Buxbaum, R. Cantor, E. Cook, H. Coon, M. Cuccaro, L. Gallagher, D. Geschwind, M. Gill, J. Haines, Judith S Miller, A. Monaco, J. Nurnberger, A. Paterson, M. Pericak-Vance, G. Schellenberg, S. Scherer, J. Sutcliffe, P. Szatmari, A. Vicente, V. Vieland, E. Wijsman, B. Devlin, S. Ennis, Joachim Hallmayer +165 moresemanticscholar +1 more sourceMIF as an oncogenic driver of low‐heterogeneity melanomas
Molecular Oncology, EarlyView.Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala +4 morewiley +1 more sourceCommon and well-documented HLA alleles: 2012 update to the CWD catalogue.
Tissue Antigens, 2013 We have updated the catalogue of common and well-documented (CWD) human leukocyte antigen (HLA) alleles to reflect current understanding of the prevalence of specific allele sequences.S. Mack, P. Cano, J. Hollenbach, Jun He, Carolyn Katovich Hurley, Derek Middleton, M. Moraes, Shalini E. Pereira, J. Kempenich, Elaine F. Reed, M. Setterholm, Anajane G. Smith, Marcel G. J. Tilanus, Margareth Torres, Michael D. Varney, C. Voorter, Gottfried Fischer, Katharina Fleischhauer, Damian Goodridge, W. Klitz, A. Little, M. Maiers, Steven G. E. Marsh, Carlheinz Müller, H. Noreen, E. Rozemuller, Alicia Sanchez-Mazas, D. Senitzer, E. Trachtenberg, M. Fernández-Viña +29 moresemanticscholar +1 more sourceDetecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda +12 morewiley +1 more sourceFEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA
Acta Biomedica Scientifica, 2012 On the basis of studying of features of structure of 7 genes determining major factors of pathogenicity of the causative agent of whooping cough - ptxA, ptxB, ptxC, ptxD, ptxE, ptxP and prn, features of genotyping variability of strains of B.pertussis ...V. A. Aleshkin, O. Yu. Borisova, N. T. Gadua, I. K. Mazurova +3 moredoaj Standardized SSR allele naming and binning among projects
BioTechniques, 2010 Simple sequence repeats (SSRs) have proven to be extremely valuable DNA markers for genetic mapping and population genetic analyses. However, data collected across laboratories or even within laboratories are difficult to combine due to challenges in ...Dennis L. Deemer, C. Dana Nelsondoaj +1 more sourceRisk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
New England Journal of Medicine, 2011 BACKGROUND
Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of biopsy-proven cases of idiopathic membranous nephropathy in a white ...H. Stanescu, M. Arcos-Burgos, A. Medlar, D. Bockenhauer, Anna Kottgen, L. Dragomirescu, C. Voinescu, N. Patel, K. Pearce, M. Hubank, H. Stephens, V. Laundy, S. Padmanabhan, A. Zawadzka, J. Hofstra, M. Coenen, M. den Heijer, L. Kiemeney, D. Bacq-Daian, B. Stengel, S. Powis, P. Brenchley, J. Feehally, A. Rees, H. Dębiec, J. Wetzels, P. Ronco, P. Mathieson, R. Kleta +28 moresemanticscholar +1 more source
