Results 131 to 140 of about 1,221,818 (402)
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Coexisting Stable Equilibria in a Multiple-allele Population Genetics Model [PDF]
arXiv, 2011 In this paper we find and classify all patterns for a single locus three- and four-allele population genetics models in continuous time. A pattern for a $k$-allele model means all coexisting locally stable equilibria with respect to the flow defined by the equations $\dot{p}_i = p_i(r_i-r), i=1,...,k,$ where $p_i, r_i$ are the frequency and marginal ...
arxiv
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
Robust identification of local adaptation from allele frequencies [PDF]
arXiv, 2012 Comparing allele frequencies among populations that differ in environment has long been a tool for detecting loci involved in local adaptation. However, such analyses are complicated by an imperfect knowledge of population allele frequencies and neutral correlations of allele frequencies among populations due to shared population history and gene flow.
arxiv
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
GENETIC CHARACTERISTICS OF THE POPULATION LIVING IN THE TERRITORY OF THE REPUBLIC OF BASHKORTOSTAN
Вестник трансплантологии и искусственных органов, 2016 Sequence based typing was used to identify human leukocyte antigen (HLA)-A, -B, -C, -DRB1 alleles in 1,064 recruited volunteers in the Republic of Bashkortostan of the Russian Federation for unrelated hematopoietic stem cell registry.
M. A. Loginova +3 more
doaj +1 more source
dnaA alleles are recessive [PDF]
Journal of Bacteriology, 1980 Dominance tests of several dnaA alleles from Escherichia coli, including two previously reported to be dominant, show that all of the mutant alleles examined are recessive to dnaA+.
openaire +3 more sources
PREVALENCE OF POLYMORPHIC VARIANTS OF GENES HLA SYSTEM IN HEALTHY DONORS OF KRASNODAR REGION
Кубанский научный медицинский вестник, 2017 Polymorphism studies major histocompatibility complex human (HLA-system) in the world, held from mid-60s, when serotyping methods revealed that in different populations are determined by different sets of options HLA-antigens.
A. I. Tlif +5 more
doaj +1 more source
Multiple sclerosis susceptibility alleles in African Americans. [PDF]
, 2010 Multiple sclerosis (MS) is an autoimmune demyelinating disease characterized by complex genetics and multifaceted gene-environment interactions. Compared to whites, African Americans have a lower risk for developing MS, but African Americans with MS have
Caillier, SJ +11 more
core
The ages of alleles and a coalescent
Advances in Applied Probability, 1986 A new coalescent is introduced to study the genealogy of a sample from the infinite-alleles model of population genetics. This coalescent also records the age ordering of alleles in the sample. The distribution of this process is found explicitly for the Moran model, and is shown to be robust for a wide class of reproductive schemes.Properties of the ...
Donnelly, P, Tavare, S
openaire +3 more sources