Results 11 to 20 of about 1,221,818 (402)
Are minor alleles more likely to be risk alleles? [PDF]
BMC Medical Genomics, 2018 Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors.
T. Kido +10 more
semanticscholar +7 more sources
Exact Solution of the Multi-Allelic Diffusion Model [PDF]
Mathematical Biosciences (2007) v209 pp124-70, 2005 We give an exact solution to the Kolmogorov equation describing genetic drift for an arbitrary number of alleles at a given locus. This is achieved by finding a change of variable which makes the equation separable, and therefore reduces the problem with an arbitrary number of alleles to the solution of a set of equations that are essentially no more ...
Baxter, G., Blythe, R. A., McKane, A. J.
arxiv +4 more sources
The Effect of Recombination on the Speed of Evolution [PDF]
, 2019 It has been a puzzling question why some organisms reproduce sexually. Fisher and Muller hypothesized that reproducing by sex can speed up the evolution. They explained that in the sexual reproduction, recombination can combine beneficial alleles that lie on different chromosomes, which speeds up the time that those beneficial alleles spread to the ...
Udomchatpitak, Nantawat
arxiv +5 more sources
Epitope prediction improved by multitask support vector machines [PDF]
We use various multitask kernels in order to improve MHC-I-peptide
binding prediction, in particular for MHC alleles for which few training data
is available. (05/02/2007), 2007 Motivation: In silico methods for the prediction of antigenic peptides binding to MHC class I molecules play an increasingly important role in the identification of T-cell epitopes. Statistical and machine learning methods, in particular, are widely used to score candidate epitopes based on their similarity with known epitopes and non epitopes.
Jacob, Laurent, Vert, Jean-Philippe
arxiv +3 more sources
Borrowed alleles and convergence in serpentine adaptation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 ACKNOWLEDGMENTS. We thank members of the L.Y. and K.B. laboratories for helpful discussions. This work was supported through the European Research Council Grant StG CA629F04E (to L.Y.); a Harvard University Milton Fund Award (to K.B.); Ruth L ...
Brian J. Arnold +7 more
semanticscholar +4 more sources
Prediction of HLA class II alleles using SNPs in an African population [PDF]
, 2012 BACKGROUND: Despite the importance of the human leukocyte antigen (HLA) gene locus in research and clinical practice, direct HLA typing is laborious and expensive.
Adeyemo, Adebowale +7 more
core +9 more sources
Molecular characterization of a species in the genus Rubus in Boyacá, Colombia [PDF]
Revista Brasileira de Fruticultura, 2021 Colombia is home to blackberry genetic resources which present a morphological diversity. The relevant characteristics related to its diversity are the presence of prickles, the shape of its leaves, the number and color of its fruits, and its enormous ...
Brigitte Liliana Moreno–Medina +1 more
doaj +1 more source
Сибирский научный медицинский журнал, 2021 Aim of the study was to investigate the immunogenetic characteristics of the potential donors of hematopoietic stem cells recruited in the North Caucasus and the distribution features of HLA alleles and multilocus haplotypes. Material and methods.
M. A. Loginova +5 more
doaj +1 more source
Comparison of short tandem repeat loci D2S1338 and D18S51 in the populations of the Republic of Srpska and the autonomous province of Vojvodina [PDF]
Scripta Medica, 2021 Introduction: Numerous human migrations between Bosnia and Herzegovina and Serbia's northern province of Vojvodina have led to the increased mixing of these population's genetic pool, leading to a reduction in genetic differences. The question is whether
Samardžić Branka +3 more
doaj +1 more source
Inference of population structure using multilocus genotype data: dominant markers and null alleles
Molecular Ecology Notes, 2007 Dominant markers such as amplified fragment length polymorphisms (AFLPs) provide an economical way of surveying variation at many loci. However, the uncertainty about the underlying genotypes presents a problem for statistical analysis.
D. Falush, M. Stephens, J. Pritchard
semanticscholar +1 more source