Are minor alleles more likely to be risk alleles? [PDF]
BMC Medical Genomics, 2018 Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors. Natural selection has led to a high tendency of risk alleles to be enriched in minor alleles in Mendelian ...
Kido, Takashi +10 more
openaire +6 more sources
Asian Journal of Transfusion Science, 2020 Background: Prevalence of rhesus (Rh) and Kell antigens in a population vary with race, ethnicity, and geographical location. With advances in immunohematology, non-D antigens, and their corresponding antibodies are increasingly being found to be ...
Sangeeta Pahuja +5 more
doaj +1 more source
RHD Positive Haplotype in D Negative Omani Blood Donor
Oman Medical Journal, 2023 The frequency of Rhesus D negative blood group in Omanis is 8.35% but the molecular background of this phenotype is unknown in the Omani population. The Rhesus D negative phenotype has a high molecular diversity.
Mujtaba Al Lawati, Badriya Al Balushi
doaj +1 more source
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. [PDF]
, 2016 The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects.
Adkisson, Michael +9 more
core +11 more sources
Differential coupling of gibberellin responses by Rht-B1c suppressor alleles and Rht-B1b in wheat highlights a unique role for the DELLA N-terminus in dormancy [PDF]
, 2017 During the Green Revolution, substantial increases in wheat (Triticum aestivum) yields were realized, at least in part, through the introduction of the Reduced height (Rht)-B1b and Rht-D1b semi-dwarfing alleles.
Chandler, Peter Michael +3 more
core +1 more source
Standardized SSR allele naming and binning among projects
BioTechniques, 2010 Simple sequence repeats (SSRs) have proven to be extremely valuable DNA markers for genetic mapping and population genetic analyses. However, data collected across laboratories or even within laboratories are difficult to combine due to challenges in ...
Dennis L. Deemer, C. Dana Nelson
doaj +1 more source
KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles. [PDF]
, 2016 KIR2DL2 and KIR2DL3 segregate as alleles of a single locus in the centromeric motif of the killer cell immunoglobulin-like receptor (KIR) gene family. Although KIR2DL2/L3 polymorphism is known to be associated with many human diseases and is an important
Bao, Ju +5 more
core +1 more source
Reliability assessment of null allele detection: inconsistencies between and within different methods [PDF]
, 2014 Microsatellite loci are widely used in population genetic studies, but the presence of null alleles may lead to biased results. Here we assessed five methods that indirectly detect null alleles, and found large inconsistencies among them.
Avise +31 more
core +1 more source
Allelic diversity of S-RNase alleles in diploid potato species [PDF]
Theoretical and Applied Genetics, 2016 The S-ribonuclease sequences of 16 S-alleles derived from diploid types of Solanum are presented. A phylogenetic analysis and partial phenotypic analysis support the conclusion that these are functional S-alleles. S-Ribonucleases (S-RNases) control the pistil specificity of the self-incompatibility (SI) response in the genus Solanum and several other ...
Daniel Dzidzienyo +5 more
openaire +5 more sources
Association between Q192R Polymorphism of Paraoxonase-1 Gene and Risk of Coronary Artery Disease: A Case-control Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Coronary Artery Disease (CAD) is a complex metabolic disorder in which lifestyle and genetic factors are known to play key roles in pathogenesis.
Harleen Kaur +4 more
doaj +1 more source