Results 11 to 20 of about 880,277 (345)
Are minor alleles more likely to be risk alleles? [PDF]
BMC Medical Genomics, 2018 Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors.
T. Kido +10 more
semanticscholar +7 more sources
Association between Q192R Polymorphism of Paraoxonase-1 Gene and Risk of Coronary Artery Disease: A Case-control Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Coronary Artery Disease (CAD) is a complex metabolic disorder in which lifestyle and genetic factors are known to play key roles in pathogenesis.
Harleen Kaur +4 more
doaj +1 more source
Inference of population structure using multilocus genotype data: dominant markers and null alleles
Molecular Ecology Notes, 2007 Dominant markers such as amplified fragment length polymorphisms (AFLPs) provide an economical way of surveying variation at many loci. However, the uncertainty about the underlying genotypes presents a problem for statistical analysis.
D. Falush, M. Stephens, J. Pritchard
semanticscholar +1 more source
Allelic diversity of S-RNase alleles in diploid potato species [PDF]
Theoretical and Applied Genetics, 2016 The S-ribonuclease sequences of 16 S-alleles derived from diploid types of Solanum are presented. A phylogenetic analysis and partial phenotypic analysis support the conclusion that these are functional S-alleles. S-Ribonucleases (S-RNases) control the pistil specificity of the self-incompatibility (SI) response in the genus Solanum and several other ...
Daniel Dzidzienyo +5 more
openaire +5 more sources
Microsatellite null alleles and estimation of population differentiation.
Molecular biology and evolution, 2007 Microsatellite null alleles are commonly encountered in population genetics studies, yet little is known about their impact on the estimation of population differentiation.
M. Chapuis, A. Estoup
semanticscholar +1 more source
Ribogospodarsʹka Nauka Ukraïni, 2016 Purpose. Study of the peculiarities of the genetic structure based on genetic-biochemical markers in age-1+ and 2+ rainbow trout of the fish farm “Sloboda Banilov”, Chernivtsi region Methodology.
Р. Mendrishora +2 more
doaj +1 more source
HLA diversity in the Russian population assessed by next generation sequencing
Медицинская иммунология, 2021 Next generation sequencing is used to determine full-length sequences of HLA genes at the 4-field (allelic) resolution. The study was aimed at determining frequency and diversity of HLA alleles in a cohort of blood donors from the Registry of the ...
E. G. Khamaganova +5 more
doaj +1 more source
Bioinform., 2015 UNLABELLED Assessing linkage disequilibrium (LD) across ancestral populations is a powerful approach for investigating population-specific genetic structure as well as functionally mapping regions of disease susceptibility. Here, we present LDlink, a web-
M. Machiela, S. Chanock
semanticscholar +1 more source
GPD1 and ADH3 Natural Variants Underlie Glycerol Yield Differences in Wine Fermentation
Frontiers in Microbiology, 2018 Glycerol is one of the most important by-products of alcohol fermentation, and depending on its concentration it can contribute to wine flavor intensity and aroma volatility.
Sebastián M. Tapia +21 more
doaj +1 more source
Clinical pharmacology and therapy, 2017 Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic activity toward a plethora of clinically important medications. Thus, single nucleotide variants and copy number variations in CYP genes are major determinants of drug ...
Yitian Zhou +2 more
semanticscholar +1 more source