Results 211 to 220 of about 141,953 (299)

Polysensitization Patterns and Age-Dependent Allergen Profiles in Children from Suzhou, China: A Component-Resolved Cross-Sectional Study. [PDF]

J Asthma Allergy
Xu Q, Zhao H, Dong Y, Lu M, Zhai Q, Cheng Z.   +5 more
europepmc   +1 more source

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy

Allergy, EarlyView.
DeAns with defined nanoscale structure reveal that conjugate size and determinant density govern IgE‐mediated effector‐cell activation in AX allergy. All DeAn generations bind to sIgE in inhibition immunoassay, but only larger DeAns trigger FcεRI‐dependent responses in mouse MC, huRBL‐2H3, and LUVA cells.
Amene Tesfaye Ayane, Maria Salas, Sara Benede, Maria J. Rodriguez‐Sanchez, Maria J. Rodriguez‐Sojo, Isabel M. Jiménez‐Sánchez, Gador Bogas, Ezequiel Perez‐Inestrosa, Cristobalina Mayorga, Juan L. Paris, Alba Rodríguez‐Nogales, María J. Torres, María I. Montañez   +12 more
wiley   +1 more source

Prevalence of Allergic Rhinitis in China Continues to Increase Without Reaching a Plateau: An Analysis of Three Waves of National Surveys From 2005 to 2019

Allergy, EarlyView.
Xiaoyu Pu, Ming Zheng, Siqi Ge, Yutong Sima, Xiaoru Yu, Zhongyi Wang, Xiangdong Wang, Luo Zhang   +7 more
wiley   +1 more source

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

Feed Components and Egg Allergenicity: Impact of Lupin and Soybean Meal Inclusion on Hen Egg Immunoreactivity (ELISA-Based Study). [PDF]

Foods
Tomczak A, Klimowicz P, Piasecka-Kwiatkowska D, Tomczyk Ł, Zielińska-Dawidziak M.   +4 more
europepmc   +1 more source

Allergen extracts and calcitriol affect IL-8 and TGF-β1 secretion in a cell line of canine oral keratinocytes [PDF]

, 2019
Cox, Eric, Hôbart, Clara, Krikilion, Eva, Pelst, Michael   +3 more
core   +1 more source

Circulating Type 2 Memory B Cell Frequency Is a Biomarker for Allergen Immunotherapy Efficacy in Patients With Allergic Rhinitis

Allergy, EarlyView.
Yue Ma, Shuying Li, Lei Ye, Lin Qiu, Jiayu Wu, Jiaying Li, Xian Feng, Wei Qian, Xiangping Yang, Huabin Li, Hongfei Lou   +10 more
wiley   +1 more source

Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201

Allergy, EarlyView.
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen, Heidi Heiniluoto, Janne Jänis, Kristiina Takkinen, Juha Rouvinen   +4 more
wiley   +1 more source

Profilin isoallergens, major but not immunodominant, from Korean melon. [PDF]

World Allergy Organ J
Shin YJ, Kim H, Lee YS, Sang M, Jeong K, Lee S, Park KH, Park JW, Jeong KY.   +8 more
europepmc   +1 more source