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Allergen nomenclature

Journal of Allergy and Clinical Immunology, 1994
This is a revision of the allergen nomenclature system which was proposed in 1986. The nomenclature is for allergens which induce IgE-mediated allergy in humans. A table of allergens with known partial or complete sequences as of December 1993 is given.
Hoffman D   +5 more
openaire   +4 more sources

Determinants of allergenicity

Journal of Allergy and Clinical Immunology, 2009
The question "What makes an allergen an allergen?" has puzzled generations of researchers, and we still do not have a conclusive answer. Despite increasing knowledge about the molecular and functional characteristics of allergens that have been identified, we still do not fully understand why some proteins are clinically relevant allergens and most are
Traidl-Hoffmann, Claudia   +2 more
openaire   +5 more sources

Cockroach Allergens: Function, Structure and Allergenicity

Protein & Peptide Letters, 2007
Cockroach allergy is a widespread health problem in the world, associated with the development of asthma. The German and American cockroach species are important producers of a wide variety of allergens. Knowledge of their structure and function contributes to understand their role in allergy and to design tools for diagnosis and immunotherapy.
Lisa D. Vailes   +4 more
openaire   +3 more sources

Allergens and Allergen Immunotherapy

1998
Allergen immonotherapy in historical perpective definition of an allergen aerobiology allergen nomenclature tree pollen allergens grass pollen allergens weed pollen allergens mold allergens biting insect allergens mite allergens cockroach and other inhalent insect allergens food allergens latex allergens drug allergens, haptens and anaphylatoxins ...
openaire   +2 more sources

The advent of recombinant allergens and allergen cloning [PDF]

open access: possibleJournal of Allergy and Clinical Immunology, 2011
When the allergen nomenclature system was adopted in 1986, allergens were identified by their behavior on electrophoresis and chromatography and by reactivity to shared antisera. Not only was this unsatisfactory for standardization, but the processes of allergic sensitization and immunotherapy could not be studied in the framework of antigen processing
openaire   +2 more sources

The Function of Allergens May Determine Allergenicity

1996
Allergenicity of an antigen in terms of Type-1 allergy has always been described as the ability of a given protein to bind to specific IgE antibodies and the potency of these allergens to crosslink cellbound IgE to induce mediator release like histamine in basophils or mast cells.
Max Schlaak   +4 more
openaire   +3 more sources

Allergen immunotherapy with cat allergen peptides

Springer Seminars in Immunopathology, 2004
Desensitising therapy for allergic diseases has changed little over almost a century of practice. Administration of increasing doses of extracts of allergen source material has been shown to be reproducibly effective when patients are carefully selected and appropriate concentrations of allergen employed.
A. Barry Kay, Mark Larché
openaire   +3 more sources

Allergen-Specific Immunotherapy with Recombinant Allergens

2011
Subcutaneous immunotherapy is a well-documented treatment of allergic rhinitis and asthma. The major limitation is the risk of anaphylactic side effects. The documentation of clinical efficacy is based on crude allergenic extracts sometimes containing varying amounts of individual allergens including allergens to which the patient may not be sensitized.
Gabrielle Pauli, Hans-Jørgen Malling
openaire   +3 more sources

Allergens

1998
Publisher Summary This chapter briefly outlines the development of allergens focusing on identification of allergy and its mechanisms, on the relevance of allergen in the pathogenesis of asthma, and on increased prevalence of the condition(s). Allergy, which is type I IgE-mediated sensitization and sequelae to predominantly inhaled allergens, has ...
openaire   +3 more sources

Allergen databases

Allergy, 2003
Allergies represent a significant medical and industrial problem. Molecular and clinical data on allergens are growing exponentially and in this article we have reviewed nine specialized allergen databases and identified data sources related to protein allergens contained in general purpose molecular databases.
Nikolai Petrovsky   +6 more
openaire   +4 more sources

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