Results 61 to 70 of about 415,351 (305)

Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort. [PDF]

, 2014
INTRODUCTION: The hypothesis that paracetamol, one of the most widely used medicines, may increase the risk of asthma and allergic disease is of obvious importance but prospective cohort data looking at dose and timing of exposure are lacking. OBJECTIVE:
Amberbir, Alemayehu, John Britton, Gail Davey (4462069), Andrea Venn, Medhin, Girmay, Girmay Medhin (347685), Britton, John, Alemayehu Amberbir (95491), Alemayehu Amberbir, Hanlon, Charlotte, Charlotte Hanlon, Andrea Venn (347686), John Britton (70864), Gail Davey (155158), Gail Davey, Charlotte Hanlon (291709), Venn, Andrea, Girmay Medhin, Davey, Gail   +18 more
core   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

The Development of Rheumatoid Arthritis–Specific Ambulatory Care–Sensitive Conditions: Results of a Consensus Process

Arthritis Care &Research, EarlyView.
Objective Ambulatory care–sensitive conditions (ACSCs) serve as indicators of access, quality, and performance of the health system. This study aimed to determine rheumatoid arthritis (RA)‐specific ACSCs for use in the evaluation of care system access and quality.
Kara Irwin, Candace H. Feldman, Claire E. H. Barber, Gabriel Fabreau, Jake Jennings, Scott Patten, Cheryl Barnabe, Inflammatory Arthritis‐Specific ACSC Consensus Process Working Group   +7 more
wiley   +1 more source

The effects of anti-sense interleukin-5 gene transferred by recombinant adeno-associated virus in allergic rats [PDF]

, 2008
The accumulation and infiltration of eosinophils in airways is one of the most important characteristics of asthma, and is mediated partly by secretion of IL-5 from Th2 lymphocytes.
Weining Xiong, Qingfeng Song, Yongjian Xu, Xiansheng Liu, Daxiong Zeng, Yong Cao, Chao Cao   +6 more
core  

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

Breastfeeding duration modified the effects of neonatal and familial risk factors on childhood asthma and allergy: a population-based study

Respiratory Research, 2021
Background Childhood asthma and allergic diseases are a significant global problem. There are inconsistent findings on the associations of delivery mode, the number of children in the household and breastfeeding with childhood asthma and allergic ...
Yabin Hu, Yiting Chen, Shijian Liu, Fan Jiang, Meiqin Wu, Chonghuai Yan, Jianguo Tan, Guangjun Yu, Yi Hu, Yong Yin, Jiajie Qu, Shenghui Li, Shilu Tong   +12 more
doaj   +1 more source

Urbanisation is associated with prevalence of childhood asthma in diverse, small rural communities in Ecuador. [PDF]

, 2011
BACKGROUND: Studies conducted in transitional communities from Africa and Asia have pointed to the process of urbanisation as being responsible for the increase in asthma prevalence in developing regions.
Barreto, Mauricio L, Oviedo, G, Oviedo, Gisela, Teles, C, M. Vaca, L. C. Rodrigues, Cooper, Philip J, Rodriguez, Alejandro, Rodriguez, A, Rodrigues, LC, M. E. Chico, Chico, ME, G. Oviedo, Chico, Martha E, Teles, Carlos, P. J. Cooper, C. Teles, M. L. Barreto, Vaca, Maritza, Erazo, Silvia, Vaca, M, Erazo, S, A. Rodriguez, Barreto, ML, S. Erazo, Rodrigues, Laura C, Cooper, PJ, Cooper, Philip   +27 more
core   +1 more source

Domestic exposure to irritant cleaning agents and asthma in women

Environment International, 2020
An adverse role of frequent domestic use of cleaning agents, especially in spray form, on asthma has been reported. However, sparse studies have investigated respiratory health effects of chronic domestic exposure to irritant cleaning agents.
Pierre Lemire, Orianne Dumas, Sébastien Chanoine, Sofia Temam, Gianluca Severi, Marie-Christine Boutron-Ruault, Jan-Paul Zock, Valérie Siroux, Raphaëlle Varraso, Nicole Le Moual   +9 more
doaj   +1 more source

The effectiveness of target therapy in patients with severe allergic asthma [PDF]

Терапевтический архив, 2019
The purpose of study was to analyze own clinical experience and assess the effectiveness in treatment of severe very poorly controlled allergic asthma patients with omalizumab.
O V Skorokhodkina, A R Valeeva, A V Luntsov, V A Pozdnyak   +3 more
doaj   +1 more source