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Epidemiological aspects of allergic conjunctivitis
Allergology International, 2020 The prevalence of ocular allergies has been increasing worldwide for the past several decades. The geographical distribution and hot spots of rhinoconjunctivitis have been documented in a global survey by the International Study of Asthma and Allergies in Childhood (ISAAC).Kazumi Fukagawa, Atsuki Fukushima, Jun Shoji, Kenichi Namba, Dai Miyazaki, Yumiko Shimizu, Shigeki Okamoto, Nobuyuki Ebihara, Eiichi Uchio +8 moreopenaire +4 more sourcesSix Injections of Modified Adjuvanted PQ Grass Is Effective and Well‐Tolerated in a Pivotal Phase III Trial
Allergy, EarlyView.A pivotal Phase III DBPC adaptive trial was conducted with PQ Grass 27600 SU. The primary endpoint EAACI‐CSMS0–6 demonstrated a highly significant, clinically meaningful improvement for PQ Grass of −0.27 points (95% CI: −0.42 to −0.12), corresponding to a relative difference of −20.3% (p = 0.0005) over placebo. Highly consistent secondary endpoints and Stefan Zielen, Jonathan A. Bernstein, Gunter J. Sturm, Marek Jutel, Oliver Pfaar, the RESONATE Investigator Group, R. Gattringer, K. Gangl, J. Potesil, T. Sykora, M. Mattauchova, P. Panzner, M. Kasl, Z. Chovancova, T. Hofstetr, J. Poloniova, A. Zlamal, J. Haas, F. Heimlich, C. Korte, S. Ballenberger, J. Grosskopf, P. Heymer, C. Bergmann, M. Froer, G. Hoheisel, U. Thieme, C. Grigat, U. Schaefer, P. El Naib, A. Schwinn, S. Runge, M. Worm, S. Pauser, M. Jandl, J.‐C. Bohn, C. von Engelhardt, A. Schaefer, J. Rieker‐Schwienbacher, M. Cuevas, S. Lassmann, Y. Yarin, T. Nyeky, I. Szanyi, V. Urban, J. Nemes, P. Borowy, Z. Siergiejko, E. Janusik, B. Tluczykont, D. Madra‐Rogacka, S. Ptaczek, I. Wojciechowska, J. Orlicz‐Widawska, M. Żurowska‐Gębala, T. Hofman, S. Tokarski, M. Bederska, A. Latos, K. Kowal, E. Markut‐Miotla, E. Pisarczyk‐Bogacka, P. Kuna, B. Majorek‐Olechowska, A. Chmielewska, B. Kucinska, C. Chwala, P. Parikh, J. Sublett, J. Weiss, J. Leflein, P. Shapero, D. McNeil, K. O’Brien, E. Sher, G. Steven, L. Ford, A. Darter, L. Clore, D. Elkayam, G. Myers, J. Matz, M. Vanderwalker, S. Smiley, J. DeAngelo, A. Montanaro, J. Delgado, W. Greisner, C. Thornblade, M. Moss, Mohamed H. Shamji, Ralph Mösges, Markus Berger, Uwe E. Berger, Lawrence DuBuske, Janice A. Layhadi, Ludger Klimek, Markus Ollert, Murray A. Skinner, Matthias F. Kramer, Pieter‐Jan de Kam +100 morewiley +1 more sourceTear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine [PDF]
, 2016 In the field of predictive, preventive and personalised medicine, researchers are keen to identify novel and reliable ways to predict and diagnose disease, as well as to monitor patient response to therapeutic agents.A Acera, A Alonso, A Enríquez-de-Salamanca, A Enríquez-de-Salamanca, A Enríquez-de-Salamanca, A Ghaffariyeh, A Jemal, A Lambiase, A Lebrecht, A Lebrecht, A Leonardi, A Leonardi, A Leonardi, A Leonardi, A Leonardi, A Leonardi, A López-Miguel, A López-Miguel, A Peral, A Rentka, A Rentka, A Riemens, A Satici, A Solomon, AM Lemp, AP Smith, B Houser, B Li, B Ujhelyi, Biomarkers Definitions Working Group, BL Kolozsvári, C Aass, C Costagliola, C Galbis-Estrada, C Galbis-Estrada, C Joffre, C Lebrun, C Salvisberg, C Symeonidis, C Tamer, CG Begley, CM Cheung, CM Tanner, CS Paiva De, D Böhm, D Devos, D Huang, D Karamichos, D Pieragostino, D Pieragostino, D Pieragostino, DK Sen, E Csősz, E Nivenius, E Papavasileiou, E Toker, E Uchio, EA Mahmoud, EB Cook, EB Cook, EM Messmer, FH Grus, G Danaei, G Geerling, G Grech, G Martino, GU Kallarackal, GW Ousler, H Lam, H Link, HG Boersma, HJ Kim, HR Taylor, HV Nema, IA Mackie, J Jin, J Shoji, J Shoji, J Soria, J Tauber, J You, J You, JB Roedl, JC Pong, JC Pong, JE Moore, JF Huang, JG Ladas, JM Holopainen, JM Holopainen, JW Jung, K Cai, KC Yoon, KC Yoon, KK Nichols, KR VanDerMeid, KS Na, KS Park, L Cocho, L Tong, L Tong, L Zhou, L Zhou, L Zhou, M Börger, M Calonge, M Mavra, M Mrugacz, M Mrugacz, M Mrugacz, M Sacchetti, M Schicht, M Tesón, M Tishler, M Zandbelt, MA Lemp, MA Mowafy, MB Abelson, MB Goren, ME Stern, MH Jagasia, ML Massingale, N Boehm, N Boehm, N Dong, N Matheis, N Thun Und Hohenstein-Blaul von, N Tomosugi, O Golubnitschaja, O Golubnitschaja, OD Schein, P Aragona, P Argüeso, P Chhadva, P Versura, PG Montan, PK Coyle, PK Coyle, PS Goedegebuure, Q Guo, R Ihnatko, R Sack, R Shetty, R Sorkhabi, R Tailor, S Chotikavanich, S Darougar, S D’Souza, S Gutman, S Hagan, S Hagan, S Rusnak, S Vujosevic, S Yavuz, SA Lim, SC Pflugfelder, SF Hamm-Alvarez, SG Wu, SM Lam, SM Lam, SS Çomoğlu, SV Aluru, SY Lee, T Göncü, T Matsumura, T Nguyen-Khuong, T Peto, T Sakimoto, T Skwor, TH Wakamatsu, V Evans, VA Smith, VV Kapetanakis, W Choi, W Choi, W Liu, X Tan, Y Ogawa, Y Ohashi, YC Tham, YS Rabinowitz, Z Lei, Z Torok, Z Torok +183 morecore +2 more sourcesThe Role of IgE in Crohn's Disease by Impairing the Capacity of Plasmacytoid Dendritic Cells to Generate FOXP3+ Tregs
Allergy, EarlyView.We uncover an unprecedented role for IgE in CD. CD patients, regardless of allergic status and similar to allergic patients, display higher levels of circulating IgE+ and FcεRI+ immune cells, including pDCs, which are concomitant to fewer Tregs.
In vitro experiments show that the anti‐IgE monoclonal antibody omalizumab restores the ability of pDCs from Andrés de la Rocha‐Muñoz, Cristina Benito‐Villalvilla, David Olivares, Sofía Sirvent, Miguel A. García‐Brenes, Alba Angelina, Leticia Martín‐Cruz, Javier Cuesta, Paolo Tassinari, Xavier Jaumont, Carlos Taxonera, Oscar Palomares +11 morewiley +1 more sourceRecombinant Hypoallergenic Cat Allergy Vaccines
Allergy, EarlyView.This study reports the construction and preclinical characterization of peptide‐carrier‐based vaccines combining all three important cat allergens (Fel d 1, Fel d 4 and Fel d 7) within single vaccine antigens, termed PreS‐Cat 1‐PreS‐Cat 5. Two subcutaneous immunizations of rabbits with PreS‐Cat 1‐5 induce equal or better antibodies blocking allergic ...Daria Trifonova, Mirela Curin, Margarete Focke‐Tejkl, Zicheng Liu, Kristina Borochova, Pia Gattinger, Marianne van Hage, Hans Grönlund, Renata Kiss, Huey‐Jy Huang, Walter Keller, Ksenja Riabova, Antonina Karsonova, Michael Kundi, Inna Tulaeva, Daria Fomina, Alexander Karaulov, Rudolf Valenta +17 morewiley +1 more sourceClinical Benefits of a Randomized Allergy App Intervention in Grass Pollen Sufferers: A Controlled Trial
Allergy, EarlyView.Different functions of an allergy app were tested for clinical benefit in a randomized, controlled trial in patients with grass pollen allergy. Participants with pollen forecast function took more medication and had fewer symptoms than participants without pollen forecast. A symptom forecast was developed based on the study data.Caroline Holzmann, Johannes Karg, Matthias Reiger, Rajiv Kharbal, Paola Romano, Sabrina Scheiwein, Claudia Khalfi, Anna Muzalyova, Jens O. Brunner, Gertrud Hammel, Athanasios Damialis, Claudia Traidl‐Hoffmann, María P. Plaza, Stefanie Gilles +13 morewiley +1 more sourceA ‘look’ into conjunctivitis
South African Family Practice, 2019 Conjunctivitis is a common condition characterised by inflammation of the conjunctiva and is the most likely diagnosis in a patient with a red eye and discharge. Acute conjunctivitis is usually a self-limiting condition or one that is easily treated with F. Kathradadoaj +1 more sourceDirect Single‐Dose Drug‐Provocation Test Is Safe for Delabelling Penicillin Low‐Risk Reactions in Adults
Allergy, EarlyView.We show that direct single‐dose provocation test was both safe and effective in delabeling penicillin allergy in low‐risk adult patients, including those with mild delayed skin reactions and those with unknown reactions, such as childhood labels and past syncope episodes. In those who react in the drug provocation test, a T‐cell mechanism was confirmed Marina Labella, Julia Rodriguez de Guzmán, Patricia Diez‐Echave, María Salas, Rubén Fernández‐Santamaría, Cristobalina Mayorga, Inmaculada Doña, María José Torres +7 morewiley +1 more sourceAllergic conjunctivitis and conjunctival provocation tests in atopic dogs. [PDF]
, 2011 INTRODUCTION:
Canine atopic dermatitis (cAD) is a very common disease, but little is known about eye involvement. The conjunctival provocation test (CPT) is used in human to study the ocular response to allergenic stimuli and to evaluate anti-allergic ...Correira, JH, Delgado, E, Lourenço-Martins, AM, Morais-Almeida, M, Neto, I, Peleteiro, MC +5 morecore +1 more source
