Results 101 to 110 of about 1,326 (169)

Global Recruiting Patterns and Placebo Response Rates in Clinical Trials of Psoriatic Arthritis and Plaque Psoriasis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Placebo effects are a significant challenge in the conduct of clinical trials. We explored how global recruitment patterns influence the extent of placebo responses in randomized controlled trials of psoriatic arthritis and plaque psoriasis.
Andreas Kerschbaumer   +8 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

open access: yesHepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo   +14 more
wiley   +1 more source

Associations of specific pesticides and incident rheumatoid arthritis among female spouses in the Agricultural Health Study

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Growing evidence suggests farming and agricultural pesticide use may be associated with rheumatoid arthritis (RA), but few studies have examined specific pesticides and RA among farm women, who may personally use pesticides or be indirectly exposed.
Christine G. Parks   +7 more
wiley   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran   +17 more
wiley   +1 more source

HLA‐DQA1*01:02 is associated with antibody multi‐reactivity with citrulline‐containing type II collagen epitopes while HLA‐DRB1*04:01 is associated with more private antibody reactivity with citrulline‐containing IgG epitopes in rheumatoid arthritis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Anti‐citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross‐reactive binding to many antigens containing short motifs, or private with little cross‐reactivity. Also, ACPA reactivity patterns differ among RA patients, including for motif‐containing epitopes in important self‐antigens like collagen ...
S. Janna Bashar   +4 more
wiley   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann   +25 more
wiley   +1 more source

There is a method to the madness, and a madness to the method: A beginner's guide to qualitative research

open access: yesAnatomical Sciences Education, EarlyView.
Abstract Qualitative research is increasingly engaged in anatomical sciences education research. However, many in the discipline are not formally trained in qualitative methodology and—like other research methods—qualitative methods are continually developed and enhanced.
Angelique N. Dueñas   +2 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

open access: yesHepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso   +16 more
wiley   +1 more source

Probable allergic contact dermatitis mimicking erythema muliforme

open access: yesPrzegląd Dermatologiczny, 2022
Agata Karny   +4 more
doaj   +1 more source

Parents information behavior: Typology of vaccine attitudes in the context of information source use

open access: yesJournal of the Association for Information Science and Technology, EarlyView.
Abstract Although some studies indicate that vaccine risks are not a major public concern, vaccine hesitancy is nevertheless increasing. The “cure” is not simply higher information‐literacy levels; many investigations emphasize that information must come from sources people trust.
Anna Mierzecka, Marcin Łączyński
wiley   +1 more source

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