Results 71 to 80 of about 32,742 (288)

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

A contemporary look at allergic conjunctivitis

Allergy, Asthma & Clinical Immunology, 2020
Allergic eye disease is common, yet often overlooked in North America. In the U.S., up to 40% of the population is deemed to be affected and this number is growing.
Pascale Dupuis, C. Lisa Prokopich, Alexander Hynes, Harold Kim   +3 more
doaj   +1 more source

Trends in cutaneous sensitization in the first 18 years of life: results from the 1989 Isle of Wight birth cohort study [PDF]

, 2012
Background:Skin prick testing (SPT) is fundamental to the practice of clinical allergy identifying relevant allergens and predicting the clinical expression of disease.
Raza, A., Karmaus, W., Arshad, S.H., Arshad, S. H., Roberts, G., Kurukulaaratchy, R.J., Dean, T., Raza, Abid, Arshad, S., Kurukulaaratchy, R., Arshad, Syed Hasan, Scott, M., Matthews, S., Kurukulaaratchy, R. J., Dean, Taraneh, Zhang, H., Kurukulaaratchy, Ramesh, Dean, Tara   +17 more
core   +1 more source

Vernal keratoconjunctivitis (spring catarrh): A review of epidemiology, pathogenesis and management

International Journal of Medicine and Health Development, 2000
Vernal keratoconjunctivitis(VKC), a common ocular disease, is one of the allergic eye diseases. It has a worldwide distribution but is more common in hot countries. Fifty per cent of sufferers are aged between 6 and 20 years. More males are affected than
Chimdi M Chuka-Okosa
doaj  

A Pragmatic Trial of a Shared Decision‐Making Intervention to Improve Medication Adherence and Outcomes in Systemic Lupus Erythematosus: The HCQ‐SAFE Study

Arthritis &Rheumatology, EarlyView.
Objective Hydroxychloroquine (HCQ) nonadherence in systemic lupus erythematosus (SLE) stemming from decision complexities can be improved with shared decision‐making (SDM) tools clarifying benefits and harms. This study aimed to develop and evaluate HCQ‐SAFE, a pictogram‐based SDM tool during SLE visits.
Caroline Packee, Jay J. Patel, Jessica Kent, Betty Chewning, Sancia Ferguson, Patricia Tellez‐Giron, David Gazeley, Christie M. Bartels, Shivani Garg   +8 more
wiley   +1 more source

Comparative transcriptional profiling of key macrophage and fibroblast subpopulations in rheumatoid arthritis‐associated lung disease

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

The immunopathogenesis and treatment of chronic allergic eye disease [PDF]

, 2000
The pathogenesis of the potentially blinding chronic ocular allergies is poorly understood, and current therapy relies on topical steroids which have vision-reducing side-effects.
Hingorani, Melanie
core  

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

Hygiene hypothesis and innate immunity. evaluating the role of environmental factors and genetic polymorphisms on the expression of receptors of the innate immune system [PDF]

, 2009
Background In ‘westernised’ countries, the prevalence of childhood asthma and allergy has risen throughout the last few decades. A series of epidemiological studies showed reduced prevalence of asthma and allergy among farmers’ children compared to non ...
Bieli, Christian
core   +1 more source

Shield ulcer: A very rare presentation

Kerala Journal of Ophthalmology, 2017
Shield ulcer is a severe form of vernal keratoconjunctivitis (VKC). Shield ulcer is an uncommon, incapacitating corneal manifestation that occurs in 3%–11% of patients suffering from VKC. Patients might present with intense itching, sensitivity to light,
Sujit Das
doaj   +1 more source