Results 191 to 200 of about 54,518 (301)

Incidence, severity and potential pathomechanism of immune‐related pruritus in melanoma patients undergoing immune checkpoint inhibitor therapy

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Pruritus is a frequent cutaneous immune‐related adverse event (irAE) associated with immune checkpoint inhibitors (ICI), impacting patients' quality of life. This study investigates the incidence, severity and management of pruritus in melanoma patients treated with ICI.
Andrea Roggo   +6 more
wiley   +1 more source

Regional Trade Agreements and International R&D Spillovers: Implications for Developing Countries

open access: yesThe Developing Economies, EarlyView.
ABSTRACT We provide new evidence on heterogeneous international research and development (R&D) spillovers from partners of regional trade agreements (RTAs) and non‐partners using a sample of 45 economies in the period 1995–2017. We construct separate R&D stocks for RTA partners and non‐partners and find that spillovers from RTA partners are stronger ...
Yukiko Sawada, Rinki Ito, Naoto Jinji
wiley   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

open access: yesThe FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova   +12 more
wiley   +1 more source

Isotopic niche plasticity of American alligators within the southern Everglades. [PDF]

open access: yesPLoS One
Denton MJ   +6 more
europepmc   +1 more source

Incidence and Characteristics of HBV Reactivation‐Related Events Following HBsAg Seroclearance: Long‐Term Follow‐up of a Population‐Based Cohort in Japan

open access: yesHepatology Research, EarlyView.
In a population‐based cohort in Japan, HBV reactivation‐related events were observed after HBsAg seroclearance, including one virologically confirmed hepatic flare occurring spontaneously without chemotherapy or immunosuppression. These findings indicate that HBsAg seroclearance does not always represent complete viral eradication, supporting the need ...
Kazumi Yamasaki   +7 more
wiley   +1 more source

An overview of consent requirements for HIV and viral hepatitis B and C testing in Europe

open access: yesHIV Medicine, EarlyView.
Abstract Background Complicated consent procedures for bloodborne virus (HIV, HBV and HCV) testing present barriers to implementation, particularly in non‐specialist healthcare settings. European and global guidelines no longer recommend written consent. An overview of testing consent requirements in Europe is lacking. Methods An online survey on legal
Annemarie Rinder Stengaard   +43 more
wiley   +1 more source

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