Results 41 to 50 of about 600,607 (269)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hydrological drought dynamic using copula functions and drought center migration in the Ganjiang river basin

Scientific Reports
Understanding the spatiotemporal evolution of hydrological drought is essential for effective drought management. This study investigated hydrological drought in Ganjiang River Basin (GRB), China from 1959 to 2019 using observed and SWAT-simulated runoff
Weilin Liu, Jingrong Zhang, Zhanxiong Zhou, Shengnan Zhu, Lina Liu, Jianzhu Li   +5 more
doaj   +1 more source

Unbalanced Allocations

CoRR, 2013
We consider the unbalanced allocation of $m$ balls into $n$ bins by a randomized algorithm using the "power of two choices". For each ball, we select a set of bins at random, then place the ball in the fullest bin within the set. Applications of this generic algorithm range from cost minimization to condensed matter physics.
openaire   +2 more sources

Allocating Capacity with Demand Competition: Fixed Factor Allocation* [PDF]

Decision Sciences, 2016
ABSTRACTWe consider a supply chain consisting of a supplier and two retailers. The supplier sells a single product to the retailers, who, in turn, retail the product to customers. The supplier has limited production capacity, and the retailers compete for the supplier's capacity and are duopolists engaged in Cournot competition for their customers ...
Jianbin Li, Xueyuan Cai, Zhixin Liu 0004
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Impacts of the Allocation Mechanism Under the Third Phase of the European Emission Trading Scheme

Energies, 2018
This paper focuses on the following two key research questions in the context of the change in allocation rules in the move from Phase I/II (2005–2012) to Phase III (2013–2020) of the European Emission Trading Scheme (EU ETS): First, how do ...
Wolfgang Eichhammer, Nele Friedrichsen, Sean Healy, Katja Schumacher   +3 more
doaj   +1 more source

Allocation Constraints in Stratification [PDF]

Communications in Statistics - Simulation and Computation, 2008
When a finite population is to be stratified, one of constraints in stratification is that sample sizes from strata may not be greater than the corresponding strata sizes and may not be smaller than two. There are several ways of treating this allocation constraint, each providing an alternative approach to stratification. In the paper it is shown that
Marcin Kozak, Pawel Jankowski
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

mSPECTRA: Email Management System of The Journal of Clinical and Diagnostic Research [PDF]

Journal of Clinical and Diagnostic Research, 2019
In an organisation with multiple departments and division of labour, email management becomes a daunting task, and choosing the right email allocation system significantly impacts the success of business communication.
Ruchi Shukla, Nikhita Gulati, Hemant Jain   +2 more
doaj   +1 more source

Balanced allocation on graphs [PDF]

Proceedings of the seventeenth annual ACM-SIAM symposium on Discrete algorithm - SODA '06, 2006
In this paper, we study the two choice balls and bins process when balls are not allowed to choose any two random bins, but only bins that are connected by an edge in an underlying graph. We show that for $n$ balls and $n$ bins, if the graph is almost regular with degree $n^ε$, where $ε$ is not too small, the previous bounds on the maximum load ...
Krishnaram Kenthapadi, Rina Panigrahy
openaire   +3 more sources