Results 31 to 40 of about 43,623 (307)

A JOINT EXPERIMENTAL ANALYSIS OF INVESTOR BEHAVIOR IN IPO PRICING METHODS [PDF]

open access: yesRAE: Revista de Administração de Empresas, 2015
This article jointly examines the differences of laboratory versions of the Dutch clock open auction, a sealed-bid auction to represent book building, and a two-stage sealed bid auction to proxy for the “competitive IPO”, a recent innovation used in a ...
Vinicio de Souza e Almeida   +1 more
doaj   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Budget-constrained Pareto-efficient allocations [PDF]

open access: yesJournal of Economic Theory, 1979
Abstract This paper is concerned with a study of budget-constrained Pareto-efficient (BCPE) allocations, i.e., allocations which given a price system satisfy a given income distribution. We prove existence, show structural stability, and establish a sufficient condition for uniqueness of BCPE allocations.
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

ANALYSIS OF TECHNICAL, ALLOCATIVE AND ECONOMIC EFFICIENCY OF RICE FARMERS IN EBONYI STATE, NIGERIA

open access: yesRussian Journal of Agricultural and Socio-Economic Sciences, 2020
Major obstacles to food security in Nigeria, is the low productivity of most staple food crops and the efficiency with which the farmers use the limited available inputs.
Nwahia O.C.   +5 more
doaj   +1 more source

ANALISIS FUNGSI PRODUKSI DAN EFISIENSI ALOKATIF USAHATANI UBI JALAR DI KECAMATAN HULU PALIK KABUPATEN BENGKULU UTARA

open access: yesJurnal Agrisep, 2019
The aims of the research are to 1) determine factors that affect the production of sweet potato, 2) to determine the level of allocative efficiency of sweet potato production inputs.
Bripen Simanjuntak   +2 more
doaj   +1 more source

Mechanization and efficiency in rice production in China

open access: yesJournal of Integrative Agriculture, 2021
Agricultural mechanization and custom machine services have developed rapidly in China, which can influence rice production efficiency in the future. We calculate technical efficiency, allocative efficiency, and scale efficiency using data collected in ...
Min SHI, Krishna P. PAUDEL, Feng-bo CHEN
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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