Compensatory Mitophagy via NEDD4/HIF-1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα. [PDF]
Adv Sci (Weinh)The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Feng D +15 more
europepmc +2 more sources
Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear [PDF]
, 2023 PurposeThicker (folded) facia lata autografts have been shown to be superior to thinner grafts and single-layered acellular human dermal (HD) allografts for superior capsular reconstruction (SCR) in biomechanical studies.
Snow, Martyn
core +1 more source
Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury [PDF]
, 2012 The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between ...
Ryan, Michael P. +4 more
core +2 more sources
Estudio de los polimorfismos de los genes transforming growth factor-beta-1, enzima de conversión de la angiotensina, y Par1/Emk1 como marcadores moleculares para el diagnóstico precoz de la nefropatía crónica del transplante. [PDF]
, 2006 [spa] La nefropatía crónica del transplante (NCT) es una enfermedad degenerativa caracterizada por el depósito de matriz extracelular. Aunque su patogenia es desconocida se ha sugerido que en ella participa el "transforming growth" factor-beta1 (TGF ...
Hueso Val, Miguel
core +6 more sources
CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. [PDF]
, 2013 CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and ...
Freeman, Gordon +46 more
core +2 more sources
Reduced CD40L expression on ex vivo activated CD4+T-lymphocytes from patients with excellent renal allograft function measured with a rapid whole blood flow cytometry procedure [PDF]
, 2004 Background: The CD40-CD40L (CD154) costimulatory pathway plays a critical role in the pathogenesis of kidney allograft rejection. In renal transplant biopsies, CD4+ CD40L+ graft-infiltrating cells were detected during chronic rejection in contrast to ...
Lederer, Stephan R. +5 more
core +1 more source
Human Acellular Dermal Allograft Patch on Traumatic Tympanic Membrane Perforation
, 2022 BACKGROUND: This study aimed to investigate the outcome of using the human acellular dermal allograft patch compared with the conventional paper patch in traumatic tympanic membrane perforation.
Lee, Dong-Han +5 more
core +1 more source
Learning Curve of Minimally Invasive C1-C2 Trans-articular Screw Fixation (MIS-TAS): Over A Period of Five Years [PDF]
Journal of Minimally Invasive Spine Surgery and Technique, 2021 Objective To evaluate the learning curve associated with minimally invasive surgery (MIS) in posterior C1-C2 trans-articular (TAS) screw fixation based on surgical and clinical parameters.
Saijyot Raut +4 more
doaj +1 more source
Non-invasive monitoring of renal transplant recipients: Urinary excretion of soluble adhesion molecules and of the complement-split product C4d [PDF]
, 2003 Background: The number of inducible adhesion molecules known to be involved in cell-mediated allograft rejection is still increasing. In addition, recent data describe complement activation during acute humoral allograft rejection.
Lederer, Stephan R. +5 more
core +1 more source
Comparison of acellular dermal matrix allograft (ADMA) and a subepithelial connective tissue graft (SCTG) for the treatment of gingival recession [PDF]
Journal of Advanced Periodontology and Implant Dentistry, 2020 Background. This study aimed to evaluate the effect of acellular dermal matrix allograft (ADMA) for the treatment of gingival recession as a substitute for subepithelial connective tissue graft (SCTG). Methods. In this controlled clinical trial, 18 teeth
Niloofar Jenabian +3 more
doaj +1 more source