Results 241 to 250 of about 149,355 (291)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Transplanting the unexpected: a case report of a heart allograft with wild-type transthyretin cardiac amyloid. [PDF]

Eur Heart J Case Rep
Jiang A, Davey R, Tweedie E, Smith S.
europepmc   +1 more source

Single‐Cell and Multiomic Analysis Reveals Neutrophil Heterogeneity and Prognostic Value in Cervical Lesions

Cancer Science, EarlyView.
This study is the first to identify a novel neutrophil subpopulation, N4, that is closely associated with the progression of cervical cancer. Characterized by high PLAU expression and specific interactions with tumor cells, N4 neutrophils were shown to promote tumor growth and immune modulation.
Ze Wang, Liang Zhuang, Shiyi Liu, Canhui Cao, Shimin Chen, Nan Yu, Xiaoyuan Huang, Tao Zhang   +7 more
wiley   +1 more source

Effect of Connective Tissue Graft as an Adjunct to Guided Bone Regeneration in the Surgical Treatment of Peri‐Implantitis: A Dual‐Center Randomized Controlled Trial

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To evaluate whether adding a connective tissue graft (CTG) to guided bone regeneration (GBR) improves clinical and radiographic outcomes in surgical peri‐implantitis treatment. Materials and Methods Thirty‐two patients with peri‐implantitis were randomly assigned to receive GBR and CTG (test group, TG) or GBR alone (control group ...
Lucrezia Paterno Holtzman, Iva Milinkovic, Marija Vuckovic, Chiara Malpassi, Marla Cuppini, Alex Solderer, Zoran Aleksic, Luca Cordaro   +7 more
wiley   +1 more source

Histopathology, Diagnosis, Management and Treatment Outcomes of Cemental Tears: A Retrospective Observational Cohort Study

International Endodontic Journal, EarlyView.
ABSTRACT Introduction Diagnosing cemental tears remains challenging, and treatment outcomes can be unpredictable; recommendations for their diagnosis and management are primarily based on case reports and anecdotal experience. Although a classification has been developed for cemental tears, its clinical applicability and importance have yet to be ...
Angeline Hui Cheng Lee, Mei Zhi Ting, May Chun Mei Wong, Chengfei Zhang   +3 more
wiley   +1 more source

Prolonged Skin Graft Survival and Histocompatibility in Highly Inbred Miniature Swine. [PDF]

Transplant Direct
Manell E, Mulder H, Arn JS, Gunes E, Chauhan I, Patwardhan S, Hong J, Batal I, Sachs DH, Weiner J.   +9 more
europepmc   +1 more source

Sirolimus for Secondary Prevention of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Recipients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

International Journal of Dermatology, EarlyView.
Meta‐analysis of randomized controlled trials shows that switching from calcineurin inhibitors (CNI) to sirolimus in kidney transplant recipients (KTRs) with prior cutaneous squamous cell carcinoma (cSCC) reduces secondary cSCC incidence but increases adverse‐event–related treatment discontinuation.
Yannick Foerster, Julia Palaras, Kristine Mayer, Tilo Biedermann, Oana‐Diana Persa   +4 more
wiley   +1 more source

Breast Sensation Restoration After Nipple Nerve Allograft Reconstruction and Postmastectomy Radiation. [PDF]

Plast Reconstr Surg Glob Open
Cartwright SB, Rossman A, Ringle MD, Land CC, Yang MY, Dougherty CE, Figy SC, Santamaria-Barria JA.   +7 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source