Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation [PDF]
Frontiers in ImmunologyBackgroundTertiary lymphoid structure (TLS) is a neogenized, ectopic lymphoid aggregate found in infected, autoimmune and tumour tissues with an activated adaptive immune response. However, a comprehensive understanding of the pathological role, function,
Lijie Ma +13 more
doaj +2 more sources
The value of urine cytologic examination findings in the diagnosis of the acute renal allograft rejection [PDF]
Vojnosanitetski Pregled, 2003 Background. Acute rejection of allograft is one of the most serious complications of renal transplantation that requires fast and precise diagnostic approach.
Tatomirović Željka +5 more
doaj +1 more source
ESC Heart Failure, 2021 Aims Allograft rejection following heart transplantation (HTx) is a serious complication even in the era of modern immunosuppressive regimens and causes up to a third of early deaths after HTx.
Peter J. Kennel +11 more
doaj +1 more source
Cell Death Discovery, 2022 Corneal allograft rejection can be seen in some patients after corneal transplantation. The present study intends to investigate whether JAK2 gene knockout affects corneal allograft rejection through regulation of dendritic cells (DCs)-induced T cell ...
Jun Hu +3 more
doaj +1 more source
Circulating endothelial cells transiently increase in peripheral blood after kidney transplantation
Scientific Reports, 2021 The diagnosis of kidney allograft rejection is based on late histological and clinical markers. Early, specific and minimally-invasive biomarkers may improve rejection diagnosis. Endothelial cells (EC) are one of the earliest targets in kidney transplant
H. Tejeda-Mora +9 more
doaj +1 more source
Frontiers in Immunology, 2021 Renal tubular epithelial cells (TECs) are the primary targets of ischemia–reperfusion injury (IRI) and rejection by the recipient’s immune response in kidney transplantation (KTx).
Randi Lassiter +3 more
doaj +1 more source
Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection. [PDF]
, 2013 To test, whether 10 genes, diagnostic of renal allograft rejection in blood, are able to diagnose and predict cardiac allograft rejection, we analyzed 250 blood samples from heart transplant recipients with and without acute rejection (AR) and with ...
Hsieh, Szu-Chuan +9 more
core +5 more sources
Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat. [PDF]
PLoS ONE, 2017 Chronic allograft nephropathy is a worldwide issue with the major feature of progressive allograft fibrosis, eventually ending with graft loss. Adenosine has been demonstrated to play an important role in process of fibrosis.
Mingliang Li +7 more
doaj +1 more source
Omics-based biomarkers for diagnosis and prediction of kidney allograft rejection [PDF]
The Korean Journal of Internal Medicine, 2022 Kidney transplantation is the preferred treatment for patients with end-stage kidney disease, because it prolongs survival and improves quality of life. Allograft biopsy is the gold standard for diagnosing allograft rejection. However, it is invasive and
Jeong-Hoon Lim +8 more
doaj +1 more source
A Review of Biomarkers of Cardiac Allograft Rejection: Toward an Integrated Diagnosis of Rejection
Biomolecules, 2022 Despite major advances in immunosuppression, allograft rejection remains an important complication after heart transplantation, and it is associated with increased morbidity and mortality.
Guillaume Coutance +2 more
doaj +1 more source