Results 111 to 120 of about 484,803 (308)

Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies

Nature Medicine, 2022
Jana Lipková, Tiffany Y. Chen, Ming Y. Lu, Richard J. Chen, Maha Shady, Mane Williams, Jingwen Wang, Zahra Noor, R. Mitchell, Mehmet Turan, Gulfize Coskun, F. Yilmaz, D. Demir, D. Nart, K. Başak, N. Turhan, S. Ozkara, Y. Banz, K. Odening, Faisal Mahmood   +19 more
semanticscholar   +1 more source

Serum Proteomic Signatures of RA Risk and Response: Analysis of the APIPPRA Trial

Arthritis &Rheumatology, Accepted Article.
Objective To identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA study participants were selected from baseline to RA onset for 46 RA progressors or to study end for 72 participants who did not develop RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source

Blocking hyaluronan synthesis alleviates acute lung allograft rejection

JCI Insight, 2021
Lung allograft rejection results in the accumulation of low–molecular weight hyaluronic acid (LMW-HA), which further propagates inflammation and tissue injury.
Jewel Imani, Kaifeng Liu, Ye Cui, Jean-Pierre Assaker, Junwen Han, Auyon J. Ghosh, Julie Ng, Shikshya Shrestha, Anthony M. Lamattina, Pierce H. Louis, Anne Hentschel, Anthony J. Esposito, Ivan O. Rosas, Xiaoli Liu, Mark A. Perrella, Jamil Azzi, Gary Visner, Souheil El-Chemaly   +17 more
doaj   +1 more source

EPSTEIN-BARR-VIRUS ASSOCIATED SYNDROMES IN IMMUNOSUPPRESSED LIVER-TRANSPLANT RECIPIENTS - CLINICAL PROFILE AND RECOGNITION ON ROUTINE ALLOGRAFT BIOPSY [PDF]

, 1990
The clinical profile and histopathologic changes in needle biopsies of the liver were studied in 10 cases of acute Epstein-Barr virus infection occurring in liver transplant recipients.
DEMETRIS, AJ, MARKIN, RS, RANDHAWA, PS, STARZL, TE   +3 more
core   +1 more source

Mechanism‐informed machine learning for individualized tacrolimus dose adjustment in the early post‐kidney transplant period

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu, Zihan Qin, Logan S. Smith, Jeong M. Park, Hao‐Jie Zhu   +4 more
wiley   +1 more source

THE DIAGNOSIS OF LIVER ALLOGRAFT ACUTE REJECTION IN LIVER BIOPSIES

Вестник трансплантологии и искусственных органов, 2011
We performed histological examination of 80 liver allograft biopsies, the diagnosis of acute rejection was proved in 34 cases. Histological changes in liver biopsies in different grades of acute rejection were estimated according to Banff classification ...
L. V. Shkalova, N. P. Mogeiko, I. M. Iljinsky, Y. G. Moysyuk, O. M. Tsirulnikova, S. V. Gautier   +5 more
doaj   +1 more source

Origin of lymph node-derived lymphocytes in human hepatic allografts [PDF]

, 1989
Hepatic allograft-derived lymph nodes were examined in the post-transplant period on order to determine the origin of lymphocytes and structural elements of the lymph node.
Chen, K, Demetris, AJ, Duquesnoy, RJ, Fung, JJ, Markus, B, Marrarri, M, Starzl, TE, Zeevi, A   +7 more
core   +1 more source

A clinicopathological study of human liver allograft recipients harboring preformed IgG lymphocytotoxic antibodies [PDF]

, 1992
Twenty‐six adult patients with preformed IgG donor lymphocytotoxic antibodies received primary liver allografts under FK 506 immunosuppression. The effect of the crossmatch‐positive state on early graft function and on the immunopathological and ...
Batts, Bird, Busch, Cerilli, Demetris, Demetris, Demetris, Dempster, Donaldson, Eggink, Giles, Gordon, Gubernatis, Gugenheim, Gugenheim, Hanto, Houssin, Ito, Iwaki, Iwatsuki, Kakizoe, Kissmeyer-Nielsen, Knechtle, Okuno, Simpson, Snover, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Takaya, Takaya, Takaya, Terada, Terasaki, Todo, Weber, Williams   +40 more
core   +1 more source

Lack of Improvement in Renal Allograft Survival Despite a Marked Decrease in Acute Rejection Rates Over the Most Recent Era

American Journal of Transplantation, 2004
Acute rejection is known to have a strong impact on graft survival. Many studies suggest that very low acute rejection rates can be achieved with current immunosuppressive protocols.
H. Meier‐Kriesche, J. Schold, T. Srinivas, B. Kaplan   +3 more
semanticscholar   +1 more source

Non-self recognition by monocytes initiates allograft rejection.

Journal of Clinical Investigation, 2014
Maturation of T cell-activating APCs directly links innate and adaptive immunity and is typically triggered by microbial infection. Transplantation of allografts, which are sterile, generates strong T cell responses; however, it is unclear how grafts ...
M. Oberbarnscheidt, Q. Zeng, Qi Li, H. Dai, Amanda L. Williams, W. Shlomchik, D. Rothstein, Fadi G Lakkis   +7 more
semanticscholar   +1 more source