Results 141 to 150 of about 484,803 (308)

Evaluation of a Decentralized Donor-Derived Cell-Free DNA Assay for Kidney Allograft Rejection Monitoring

Transplant International
Donor-derived cell-free DNA (dd-cfDNA) is an emerging non-invasive biomarker for allograft injury detection. This study aimed to evaluate a new, decentralized dd-cfDNA testing kit against a centralized dd-cfDNA testing service broadly utilized in the ...
Alexandre Loupy, Alexandre Loupy, Anaïs Certain, Narin S. Tangprasertchai, Maud Racapé, Cindy Ursule-Dufait, Kawthar Benbadi, Marc Raynaud, Evgeniya Vaskova, Corina Marchis, Sílvia Casas, Tim Hague, Oriol Bestard, Delphine Kervella, Carmen Lefaucheur, Carmen Lefaucheur, Thierry Viard, Olivier Aubert, Olivier Aubert   +18 more
doaj   +1 more source

The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection

Journal of Immunology Research, 2017
The control of gene expression by microRNAs (miRNAs, miR) influences many cellular functions, including cellular differentiation, cell proliferation, cell development, and functional regulation of the immune system. Recently, miRNAs have been detected in
Matthias Hamdorf, Satoru Kawakita, Matthew Everly   +2 more
doaj   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

Polyglycolic Acid Polymer Versus Porcine Small Intestine Submucosa Graft After Plaque Incision in Peyronie's Disease: A Comparative Study

Andrology, EarlyView.
ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost, Leonardo Seligra Lopes, Pedro Caetano Edler Zandoná, Jovânio Fernandes da Rosa, Pedro Fernandes Lessa, Felipe Placco Araujo Glina, Nívio Pascoal Teixeira, Sidney Glina   +7 more
wiley   +1 more source

Analysis of the Th1/Th2 Paradigm in Transplantation: Interferon-γ Deficiency Converts Th1-Type Proislet Allograft Rejection to a Th2-Type Xenograft-Like Response

Cell Transplantation, 1999
The rejection mechanisms for fetal proislet allografts and pig proislet xenografts in mice are characterized by different intragraft cytokine mRNA profiles and cellular responses.
Charmaine J. Simeonovic, Michelle J. Townsend, Gunasegaran Karupiah, J. Dennis Wilson, Jodie C. Zarb, David A. Mann, Ian G. Young   +6 more
doaj   +1 more source

Pancreatic transplantation at the University of Pittsburgh. [PDF]

, 2004
Campath-1H preconditioning with tacrolimus monotherapy is an effective immunosuppressive regimen for pancreas transplantation, with acceptable patient and graft survival rates early after transplantation.
Abu-Elmagd, K, Basu, A, Bond, G, Khan, A, Marcos, A, Mazariegos, G, Reyes, J, Shapiro, R, Sindhi, R, Starzl, TE, Tan, HP, Thai, NL, Tom, K   +12 more
core  

AI‐Assisted Decision‐Making for End‐Stage Organ Failure: Opportunities and Ethical Concerns

Artificial Organs, EarlyView.
Artificial intelligence (AI) can help physicians make better decisions for people with serious organ problems by analyzing medical data to predict outcomes. Patients want AI to support, not replace, personal care from doctors. Collaboration among experts ensures AI tools respect patient values and privacy.
John W. Haller, Olga D. Brazhnik, Kathleen N. Fenton   +2 more
wiley   +1 more source

Impact of co-blocking the costimulatory signals on immune-related genes after high-risk rabbit corneal allograft using 2nd-generation DNA sequencing technology

Genetics and Molecular Biology
The aim of this study was to evaluate the impact and mechanism of co-blocking of costimulatory signals CD28-B7-CD40-CD40L during immune allograft rejection. Forty-eight recipient rabbits were prepared as a high-risk corneal allograft model. After surgery,
Hai-Xia Zhao, Xin-Yu Li, Wen-Ying Guan, Xiao-Tong Han   +3 more
doaj   +1 more source

Congenital aniridia: European COST action ANIRIDIA‐NET guidelines for diagnosis, management and care

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare ocular disorder affecting the majority of eye structures and can be associated with systemic manifestations. The main visible phenotypic characteristic is the partial or complete absence of the iris; however, foveal hypoplasia is a more frequent and reliable clinical sign. Other ocular comorbidities are associated
Davide Romano, Vito Romano, Alejandra Daruich, Giulio Ferrari, Matthieu Robert, Francesco Semeraro, Neil Lagali, Dominique Bremond‐Gignac, the ANIRIDIA‐NET Clinical Guidelines Working Group, Miriam Barbany, Claus Cursiefen, Stefano Ferrari, Francisco Figueiredo, Christina Grupcheva, Jesper Hjortdal, Elke Kreps, Erlend Landsend, Laura Mauring, Hilde Pedersen, Nora Szentmáry, Bogumil Wowra, the Aniridia‐Europa and Geniris Working Group, Sophie Valleix, Juan Álvarez de Toledo, James Lauderdale, Tor Paaske Utheim, Paolo Rama   +26 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source