Hyperacute Allograft Rejection [PDF]
Definitions, 2020 An immediate rejection of transplanted tissue caused by the presence of preformed antibodies to donor human leukocyte antigens.
openaire +2 more sources
The ratio of circulating regulatory T cells (Tregs)/Th17 cells is associated with acute allograft rejection in liver transplantation. [PDF]
PLoS ONE, 2014 CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) and Th17 cells are known to be involved in the alloreactive responses in organ transplantation, but little is known about the relationship between Tregs and Th17 cells in the context of liver alloresponse.
Ying Wang +9 more
doaj +1 more source
Cervical Cancer-Associated Human Papillomavirus 16 E7 Oncoprotein Inhibits Induction of Anti-Cancer Immunity by a CD4+ T Cell Dependent Mechanism [PDF]
, 2009 Attempts to develop therapeutic vaccines against cervical cancer have been proven difficult. One of the major causes of the failure is due to the use of the wrong mouse models based on transplantable tumours in testing the efficacy of vaccines.
Germain J. Fernando +3 more
core +2 more sources
Scientific Reports, 2019 Pathologic diagnoses mainly depend on visual scoring by pathologists, a process that can be time-consuming, laborious, and susceptible to inter- and/or intra-observer variations.
Young-Gon Kim +7 more
semanticscholar +1 more source
The XIIIth Banff Conference on Allograft Pathology: The Banff 2015 Heart Meeting Report: Improving Antibody-Mediated Rejection Diagnostics: Strengths, Unmet Needs, and Future Directions. [PDF]
, 2017 The 13th Banff Conference on Allograft Pathology was held in Vancouver, British Columbia, Canada from October 5 to 10, 2015. The cardiac session was devoted to current diagnostic issues in heart transplantation with a focus on antibody-mediated rejection
Angelini, A +18 more
core +1 more source
Systematic Review of the Safety of Immune Checkpoint Inhibitors Among Kidney Transplant Patients
Kidney International Reports, 2020 Introduction: Kidney transplant (Ktx) recipients are excluded from clinical trials of immune checkpoint inhibitors. The aim of this systematic review was to assess the safety of immune checkpoint inhibitors among Ktx patients.
Sandhya Manohar +4 more
doaj +1 more source
Potential Roles of Long Noncoding RNAs as Therapeutic Targets in Organ Transplantation
Frontiers in Immunology, 2022 Organ transplantation is the most preferred treatment option for end-stage organ diseases; however, allograft rejection is the major hurdle in successful long-term transplant survival.
Saeedeh Salehi +5 more
doaj +1 more source
Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]
, 2017 Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L +3 more
core +4 more sources
Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection
New England Journal of Medicine, 2019 Background In the context of kidney transplantation, genomic incompatibilities between donor and recipient may lead to allosensitization against new antigens.
N. Steers +44 more
semanticscholar +1 more source
Reduced CD40L expression on ex vivo activated CD4+T-lymphocytes from patients with excellent renal allograft function measured with a rapid whole blood flow cytometry procedure [PDF]
, 2004 Background: The CD40-CD40L (CD154) costimulatory pathway plays a critical role in the pathogenesis of kidney allograft rejection. In renal transplant biopsies, CD4+ CD40L+ graft-infiltrating cells were detected during chronic rejection in contrast to ...
Friedrich, N. +5 more
core +1 more source