Results 81 to 90 of about 484,803 (308)

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively – a pilot study

Journal of Cardiothoracic Surgery, 2009
Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection ...
Helber Uwe, Schroeder Stephen, Aebert Hermann, Burgstahler Christof, Usta Engin, Kopp Andreas F, Ziemer Gerhard   +6 more
doaj   +1 more source

Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

PLoS ONE, 2016
Objective Despite substantial progress in recent years, graft survival beyond the first year still requires improvement. Since modern immunosuppression addresses mainly T-cell activation and proliferation, we studied macrophage infiltration into the ...
T. Bergler, B. Jung, F. Bourier, L. Kühne, M. Banas, P. Rümmele, Simone Wurm, B. Banas   +7 more
semanticscholar   +1 more source

The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell– and antibody‐mediated rejection

American Journal of Transplantation, 2020
The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification ...
A. Loupy, M. Haas, C. Roufosse, M. Naesens, B. Adam, M. Afrouzian, E. Akalin, N. Alachkar, S. Bagnasco, J. Becker, L. Cornell, M. C. Clahsen‐van Groningen, A. Demetris, D. Dragun, J. Duong van Huyen, A. Farris, A. Fogo, I. Gibson, D. Glotz, Juliette Gueguen, Ž. Kikić, N. Kozakowski, E. Kraus, C. Lefaucheur, H. Liapis, R. Mannon, R. Montgomery, B. Nankivell, V. Nickeleit, P. Nickerson, M. Rabant, L. Racusen, P. Randhawa, B. Robin, I. Rosales, R. Sapir-Pichhadze, C. Schinstock, D. Serón, H. Singh, R. Smith, M. Stegall, A. Zeevi, K. Solez, R. Colvin, M. Mengel   +44 more
semanticscholar   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

Advanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun, Long Zhao, Zhen Shi, Jingting Wang, Shang Yang, Xia Qi, Hengrui Zhang, Ting Wang, Weiyun Shi   +8 more
wiley   +1 more source

M2 Macrophages Serve as Critical Executor of Innate Immunity in Chronic Allograft Rejection

Frontiers in Immunology, 2021
Allograft functional failure due to acute or chronic rejection has long been a major concern in the area of solid organ transplantation for decades. As critical component of innate immune system, the macrophages are unlikely to be exclusive for driving ...
Hanwen Zhang, Zhuonan Li, Wei Li
doaj   +1 more source

Late Failing Heart Allografts: Pathology of Cardiac Allograft Vasculopathy and Association With Antibody‐Mediated Rejection

American Journal of Transplantation, 2016
In heart transplantation, there is a lack of robust evidence of the specific causes of late allograft failure. We hypothesized that a substantial fraction of failing heart allografts may be associated with antibody‐mediated injury and immune‐mediated ...
A. Loupy, Claire Toquet, P. Rouvier, T. Beuscart, M. Bories, S. Varnous, Romain Guillemain, S. Pattier, C. Suberbielle, Pascal Leprince, C. Lefaucheur, X. Jouven, P. Bruneval, J. P. Huyen   +13 more
semanticscholar   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source