Results 121 to 130 of about 1,157,735 (237)

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

Clinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout, Aanisah Hanuun, J. G. Coen van Hasselt, Rob C. van Wijk   +3 more
wiley   +1 more source

Estimating biomass and carbon stock in orange trees (Citrus sinensis L. Osbeck) of the São Paulo and southwestern Minas Gerais citrus belt, Brazil

Agrosystems, Geosciences & Environment
The living biomass and carbon stock of Citrus sinensis (L. Osbeck) orchards from the citrus belt in the states of São Paulo and southwestern Minas Gerais, Brazil, is receiving increasing attention due to its role in the carbon balance of citrus ...
Lauro Rodrigues Nogueira Jr., Carlos Cesar Ronquim, José Carlos Barbosa, Vinicius Gustavo Trombin, Roseli Reina, Fernando Alvarinho Delgado, Fernando Antônio dePádua Paim   +6 more
doaj   +1 more source

Allometric equations and carbon sequestration potential of mango (Mangifera indica) and avocado (Persea americana) in Kenya

Trees, Forests and People
Reliable biomass estimates are needed to quantify the climate benefits of fruit trees and include them in landscape restoration and international commitments such as the Nationally Determined Contributions under the Paris Agreements.
Shem Kuyah, Catherine Muthuri, Denis Wakaba, Athanase Rusanganwa Cyamweshi, Paul Kiprotich, Athanase Mukuralinda   +5 more
doaj   +1 more source

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Nonlinear Allometric Equation for Crop Response to Soil Salinity

Journal of Stress Physiology & Biochemistry, 2015
Crop response to soil salinity has been extensively studied, from empirical works to modelling approach, being described by different equations, first as a piecewise linear model. The equation employed can differ with actual response, causing miscalculation in practical situations, particularly at the higher extremes of the curve.
E. Misle, B. Kahlaoui
openaire   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Spatial variation in liana effects on host‐tree allometry and biomass in an intact tropical forest

Ecography, EarlyView.
Lianas are increasing in abundance across the tropics, yet local spatial variation in their effects on host‐tree allometry and biomass, and the drivers of this variation within forests, remain poorly understood. Using field inventory, drone photogrammetry, and terrestrial laser scanning (TLS) across a 50‐ha plot on Barro Colorado Island, Panama, we ...
Sruthi M. Krishna Moorthy, Félicien Meunier, Stefan A. Schnitzer, Kim Calders, David M. DeFilippis, Antonio Aguilar, Nancy Pausenberger, Marco D. Visser, Helene C. Muller‐Landau, Hans Verbeeck   +9 more
wiley   +1 more source

Simultaneous 3/4‐power scaling of leaf mass and 2/3‐power scaling of leaf area with stem mass in plants

Grassland Research, EarlyView.
Abstract Background Plant allometry theory developed in the last century focused on 2/3‐power scaling, determined by light interception considerations. More recently, 3/4‐power scaling based on the properties of vascular distribution networks has been proposed.
Cory Matthew, Hans Pretzsch, Rüdiger Grote   +2 more
wiley   +1 more source

Allometric equations for estimating biomass and carbon stocks of on-farm bamboo species in the agricultural landscapes of Kenya

Advances in Bamboo Science
The accurate estimation of above-ground biomass is critical for characterizing ecosystem function and accounting for carbon stocks. Cost-effective estimation of carbon stocks is required to understand the role of bamboo in climate change mitigation and ...
John N. Kigomo, Justus Mukovi, Nancy Bor, Betty Leshaye, Titus Cheruiyot, Margaret Kuria   +5 more
doaj   +1 more source