Results 121 to 130 of about 14,888 (262)

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

Clinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout, Aanisah Hanuun, J. G. Coen van Hasselt, Rob C. van Wijk   +3 more
wiley   +1 more source

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Species-specific allometric models for estimating aboveground biomass and carbon stocks of plantation forests in northcentral Ethiopia. [PDF]

Sci Rep
Reta GT, Tolera M, Mokria M.
europepmc   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Dataset for developing allometric models to estimate aboveground biomass in secondary tropical dry forests of western Mexico. [PDF]

Data Brief
Bojórquez A, Martínez-Yrízar A, Búrquez A, Jaramillo VJ, Mora F, Balvanera P, Álvarez-Yépiz JC.   +6 more
europepmc   +1 more source

Orthodentine‐osteodentine and osteocytic‐anosteocytic transition inferred from Silurian stem chondrichthyan dermal jawbones with ever‐white teeth overgrown by brown denticles

Developmental Dynamics, EarlyView.
Abstract Background The dentigerous jawbones of a 423‐million‐year‐old stem chondrichthyan (ischnacanthid acanthodian) carry a characteristic combination of multi‐row non‐shedding white teeth with brownish overgrowing denticles. The color distinction makes it a good model for observing the interaction between two odontode lineages, but the nature of ...
Jia‐Cih Kang, Henning Blom, Tiiu Märss, Donglei Chen   +3 more
wiley   +1 more source

Multispecies allometric models for estimating aboveground biomass in plantation and natural dry Afromontane forests in northcentral Ethiopia. [PDF]

PLoS One
Reta GT, Tolera M, Mokria M.
europepmc   +1 more source

Spatial variation in liana effects on host‐tree allometry and biomass in an intact tropical forest

Ecography, EarlyView.
Lianas are increasing in abundance across the tropics, yet local spatial variation in their effects on host‐tree allometry and biomass, and the drivers of this variation within forests, remain poorly understood. Using field inventory, drone photogrammetry, and terrestrial laser scanning (TLS) across a 50‐ha plot on Barro Colorado Island, Panama, we ...
Sruthi M. Krishna Moorthy, Félicien Meunier, Stefan A. Schnitzer, Kim Calders, David M. DeFilippis, Antonio Aguilar, Nancy Pausenberger, Marco D. Visser, Helene C. Muller‐Landau, Hans Verbeeck   +9 more
wiley   +1 more source

A comprehensive dataset of above-ground forest biomass from field observations, machine learning and topographically augmented allometric models over the Kashmir Himalaya. [PDF]

Data Brief
Kashani SDR, Jan FZ, Bhat IA, Najar NA, Rashid I.   +4 more
europepmc   +1 more source