Results 131 to 140 of about 10,696 (271)

Uncovering allometric scaling in Odonata Wings through automated image analy-sis: Insights into wing critical crack length

, 2023
Shahab Eshghi, Hamed Rajabi, Shaghayegh Shafaghi, Fatemeh Nabati, Sana Nazerian, A. Darvizeh, Stanislav N. Gorb   +6 more
openalex   +2 more sources

Optimizing Body Size‐Based Dosing Approaches for Antibody–Drug Conjugates

Clinical Pharmacology &Therapeutics, EarlyView.
Optimized dosing precision of antibody–drug conjugates (ADCs) remains challenging due to narrow therapeutic indices, efficacious doses near the maximum tolerated dose, and substantial interindividual variability in exposure. Body size‐based dosing can reduce exposure variability when the allometric scaling exponent for clearance α = 1 but may over‐ or ...
Andrew B. SyBing, Diane D. Wang
wiley   +1 more source

Tylosin Dosage Adjustment Based on Allometric Scaling in Male Turkeys. [PDF]

Antibiotics (Basel), 2021
Poźniak B, Tikhomirov M, Bobrek K, Jajor P, Świtała M.   +4 more
europepmc   +1 more source

Interspecific allometric scaling in eDNA production in fishes reflects physiological and surface area allometry [PDF]

, 2022
Matthew C. Yates, T. W. Wilcox, Mark Y. Stoeckle, Daniel D. Heath   +3 more
openalex   +1 more source

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

Clinical Pharmacology &Therapeutics, EarlyView.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu, Farina Hellmann, Xiaowei Zang, Nele Plock, Keyur Parmar, Radha A. Railkar, S. Y. Amy Cheung, Brian M. Maas, Ferdous Gheyas   +8 more
wiley   +1 more source

Changes in the ideal body shape associated with adolescent rowing‐ergometry performance following a 6‐week training intervention: New scaling insights using three‐dimensional allometry

European Journal of Sport Science
Scaling, to remove the effects of body size, is an important methodological approach for enabling an equitable comparison of performance differences between individuals who vary in anthropometric characteristics.
Alan M. Nevill, Grace W. M. Walters, Karah J. Dring, Benjamin A. Nevill, Simon B. Cooper, John G. Morris   +5 more
doaj   +1 more source

Neuroanatomical norms in the UK Biobank: The impact of allometric scaling, sex, and age. [PDF]

Hum Brain Mapp, 2021
Williams CM, Peyre H, Toro R, Ramus F.
europepmc   +1 more source

Population Pharmacokinetic and Exposure‐Efficacy Analysis of Baloxavir Marboxil for Influenza Treatment and Post‐Exposure Prophylaxis in Children

Clinical Pharmacology &Therapeutics, EarlyView.
Baloxavir acid (baloxavir), the active metabolite of the prodrug baloxavir marboxil, is a selective inhibitor of the influenza virus cap‐dependent endonuclease. The population pharmacokinetic (popPK) profile of baloxavir in adults/adolescents has been described previously.
Sylvie Retout, Stefan De Buck, Jacques Gaudreault, Sébastien Jolivet, Vincent Duval, Valérie Cosson, Marie‐Laure Delporte   +6 more
wiley   +1 more source

Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings. [PDF]

MAbs, 2021
Germovsek E, Cheng M, Giragossian C.
europepmc   +1 more source

Population Pharmacokinetics of Dupilumab in Adults, Adolescents, and Children With Eosinophilic Esophagitis

Clinical Pharmacology &Therapeutics, EarlyView.
Dupilumab, a fully human monoclonal antibody that blocks key drivers of type 2 inflammation, is approved across 8 diseases, including eosinophilic esophagitis. Subcutaneous dupilumab 300 mg weekly improved outcomes vs. placebo in adults (aged ≥ 18 years) and adolescents (aged ≥ 12 to < 18 years) during the phase III LIBERTY EoE TREET study (NCT03633617)
Jenny‐Hoa Nguyen, Mirna Chehade, Evan S. Dellon, Allen Radin, Jason Chittenden, Mohamed A. Kamal, Margee Louisias, Christine Xu, Matthew P. Kosloski   +8 more
wiley   +1 more source