Results 171 to 180 of about 10,696 (271)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Echocardiographic reference intervals with allometric scaling of 823 clinically healthy rhesus macaques (Macaca mulatta). [PDF]

BMC Vet Res, 2020
Ueda Y, Duler LMM, Elliot KJ, Sosa PD, Roberts JA, Stern JA.   +5 more
europepmc   +1 more source

Cardiovascular Proportionality of Modern Pigs : Are we breaking the allometric scaling laws ?

, 2017
G. J. van Essen
openalex   +1 more source

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude [PDF]

, 2016
Vasudev Kantae, Elke H. J. Krekels, Anita Ordas, Oskar González, Rob C. van Wijk, Amy C. Harms, Péter Rácz, Piet H. van der Graaf, Herman P. Spaink, Thomas Hankemeier   +9 more
openalex   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

A population pharmacokinetic model using allometric scaling for baricitinib in patients with juvenile idiopathic arthritis. [PDF]

CPT Pharmacometrics Syst Pharmacol
Decker RL, Steven Ernest C, Radtke DB, Wang R, Araújo J, Keller SY, Zhang X.   +6 more
europepmc   +1 more source

Supplementary Data "Evaluating the absence of allometric scaling for hepatic microsomal Phase I and Phase II xenobiotic biotransformation among mammals"

Luke Ockhuijsen, Ad M.J. Ragas, Aalbert Jan Hendriks   +2 more
openalex   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Prediction of Clearance of Monoclonal and Polyclonal Antibodies and Non-Antibody Proteins in Children: Application of Allometric Scaling. [PDF]

Antibodies (Basel), 2020
Mahmood I.
europepmc   +1 more source

Temporal changes in sex-specific cryptic sexual dimorphism and allometric scaling in the long-lived Alpine swift Tachymarptis melba

Michela Natalina Dumas, Pierre Bize, Julien G. A. Martin   +2 more
openalex   +1 more source