Results 251 to 260 of about 10,696 (271)

Pharmacokinetic Allometric Scaling of Oligonucleotides

Nucleic Acid Therapeutics, 2011
The objective of this study was to evaluate the predictive performance of interspecies scaling of oligonucleotides to predict clearance and volume of distribution at steady state in humans from animal data. The human pharmacokinetic parameters were predicted using 1, 2, or at least 3 animal species.
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Allometric scaling in animals and plants

Journal of Mathematical Biology, 2001
In this paper we give a derivation for the allometric scaling relation between the metabolic rate and the mass of animals and plants. We show that the characteristic scaling exponent of 3/4 occurring in this relation is a result of the distribution of sources and sinks within the living organism.
Dreyer, Olaf, Puzio, Raymond
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Allometric scaling of clearance in dogs

Journal of Veterinary Pharmacology and Therapeutics, 2009
Most drugs indicated for use in dogs are labeled for administration on a mg/kg basis. Such dosing recommendations are grounded on an assumption that total body clearance (Cl) scales in a manner directly proportional to body weight (i.e. that it scales with an allometric exponent of 1). Despite the critical nature of this assumption (the range of normal
M, Martinez, I, Mahmood, R P, Hunter
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EMERGENCE OF ALLOMETRIC SCALING IN GENEALOGICAL TREES [PDF]

Advances in Complex Systems, 2004
We investigate the emergence of power-law scalings in genealogical trees. Especially, we study the topological properties of genealogical trees both in the neutral evolution and the selective evolution. In all instances, we observe that the topologies of these trees are well described by a power-law scaling [Formula: see text], where Akis the number of
PAULO R. A. CAMPOS, VIVIANE M. DE OLIVEIRA, LEONARDO P. MAIA   +2 more
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Allometric scaling in temporal integration

2021
A relatively well-defined upper limit of 2±1 seconds appears in human cognition as a proximity constraint for temporal integration. This interval functions as a timescale and is an important determinant of grouping in the temporal domain that allows for emergent relationships between otherwise discrete stimuli.
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Allometric Scaling for Character Design

Computer Graphics Forum, 2011
AbstractGeometric scaling transformations do not respect the biological processes which govern the size and shape of living creatures. In this paper, we describe an approach to scaling which can be related to biological function. We use known biological laws of allometry which are expressed as power laws to control the mesh deformation in the frequency
T. McGraw, T. Kawai, J. Richards
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Allometric Scaling and Central Source Systems

Physical Review Letters, 2001
Physical Review ...
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Allometric scaling laws of metabolism

Physics of Life Reviews, 2006
Abstract One of the most pervasive laws in biology is the allometric scaling, whereby a biological variable Y is related to the mass M of the organism by a power law, Y = Y 0 M b , where b is the so-called allometric exponent. The origin of these power laws is still a matter of dispute mainly because biological laws, in general, do not ...
Jafferson Kamphorst Leal da Silva, Guilherme J.M. Garcia, Lauro A. Barbosa   +2 more
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Allometric scaling of pegylated liposomal anticancer drugs

Journal of Pharmacokinetics and Pharmacodynamics, 2011
Pegylated liposomal formulations contain lipid conjugated to polyethylene glycol. The disposition of encapsulated drug is dictated by the composition of the liposome, thus altering the pharmacokinetic (PK) profile of the drug. Allometric scaling is based on a power-log relationship between body weight (W) and drug clearance (CL) among mammals and has ...
Caron, W.P., Clewell, H., Dedrick, R., Ramanathan, R.K., Davis, W.L., Yu, N., Tonda, M., Schellens, J.H.M., Beijnen, J.H., Zamboni, W.C.   +9 more
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Allometric scaling in the coronary arterial system

The International Journal of Cardiovascular Imaging, 2008
Biological variables such as basal metabolic rate scale with body mass through a power law relationship. The coronary arterial system also exhibits power law relations between morphological parameters such as total distal arterial length and lumen volume.
Huy Q, Le, Jerry T, Wong, Sabee, Molloi
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