Results 251 to 260 of about 45,108 (330)

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Unraveling Wing Shape Variation in Malaria Mosquitoes from the Arctic Edge: A Geometric Morphometric Study in Western Siberia. [PDF]

Animals (Basel)
Calderon X, Artemov G, Burlak VA, Alexeeva S, Hernández-P R, Suazo MJ, Pérez LM, Benítez HA, Correa M.   +8 more
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Wing Morphology, Foraging Strategies, and Flight Performance in Six Sympatric Species of Molossid Bats (Chiroptera: Molossidae) from Argentina. [PDF]

Integr Org Biol
Argoitia MA, Teta P, Cassini GH.
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Adaptations in wing morphology rather than wingbeat kinematics enable flight in small hoverfly species. [PDF]

Elife
Le Roy C, Tervelde N, Engels T, Muijres FT.   +3 more
europepmc   +1 more source

New perspectives on head and neck allometry and ecomorphology in tetrapods

Biological Reviews, EarlyView.
ABSTRACT The skull and neck are vital parts of the body, influencing feeding ecology, habitat exploitation and locomotion. Numerous studies have therefore sought to understand how the size of these segments vary with ecology and scale with overall body size.
Alice E. Maher, Philip G. Cox, Thomas W. Maddox, James D. Gardiner, Karl T. Bates   +4 more
wiley   +1 more source

Allometry of cell types in planarians by single-cell transcriptomics. [PDF]

Sci Adv
Emili E, Pérez-Posada A, Vanni V, Salamanca-Díaz D, Ródriguez-Fernández D, Christodoulou MD, Solana J.   +6 more
europepmc   +1 more source

Homo luzonensis and the role of homoplasy in the morphology of hominin insular species

Cladistics, EarlyView.
Abstract Homo luzonensis lived during the upper Pleistocene in the northern Philippines, east of the Wallace line. The few specimens attributed to this species show a mosaic of plesiomorphies for the genus Homo and apomorphies found in upper Pleistocene Homo species.
Pierre Gousset, Jérémie Bardin, Isabelle Rouget, Armand S. Mijares, Florent Détroit   +4 more
wiley   +1 more source

Soluble Sema4D From γδ T Cells Exerts Osteoblast Inhibition via Plexin‐B/mTOR Signalling Contributing to Pathogenesis of Bisphosphonate‐Related Osteonecrosis of the Jaws

Cell Proliferation, EarlyView.
Schematic summarizing the pathway of sSema4D from γδ T cells inhibiting osteoblast differentiation in BRONJ. ABSTRACT Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe complication in patients undergoing long‐term bisphosphonate therapy, while our knowledge on the pathogenesis of BRONJ is far from sufficient.
Lingling Ou, Shijia Qiao, Zhuoyi Liao, Xiner Tan, Hui Huang, Zhiyan Zhou, Ruhui Luo, Weijun Zeng, Yan Yang, Zhongxuan Zhang, Jingchen Chen, Shengli Wang, Yiqin Jiang, Jianlei Hao, Yuqin Shen, Longquan Shao   +15 more
wiley   +1 more source